Fracture of femural shaft. Fracture of shaft of femur
Conditions
Interventions
Intervention 1: infusion of dexmedetomidine hydrochloride as 0.5µg/kg/h diluted in normal saline. Intervention 2: same volume of normal salin as dexmedetomidine group.
Treatment - Drugs
Placebo
infusion of dexmedetomidine hydrochloride as 0.5µg/kg/h diluted in normal saline
same volume of normal salin as dexmedetomidine group
Sponsors
?Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 55 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients with femoral shaft fracture who were candidates for elective surgery under general anesthesia; between 15 and 55 years; ASA Class I, II Exclusion criteria: positive history of any cardiac or hepatic problem; addiction to any specific drug; using anti hypertensive, psychiatric, agonist or antagonist a-2 receptor agents; basal heart rate less than 60/min; pregnant patient; patients who had blood loss of more than 1 liter during surgery; patients for whom the time of operation took more than 3 hours
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NT pro BNP. Timepoint: before induction and 24 hours after surgry. Method of measurement: blood level. | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic blood pressure. Timepoint: every 30 min from induction until end of surgry. Method of measurement: based on mmHg.;Diastolic blood pressure. Timepoint: every 30 min from induction until end of surgry. Method of measurement: based on mmHg.;Pulse rate. Timepoint: every 30 min from induction until end of surgry. Method of measurement: per minute. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Elham Memary
Shahid Beheshti University of Medical Sciences
Outcome results
None listed