Chronic hepatitis C. Chronic viral hepatitis C
Conditions
Interventions
Intervention 1: Intervention group: Monthly injection of 1000microgr vitamin b12 produced by Osveh company for 3 months totally. Intervention 2: Control group: Control group will not receive any medi
Treatment - Drugs
Intervention group: Monthly injection of 1000microgr vitamin b12 produced by Osveh company for 3 months totally.
Control group: Control group will not receive any medication
Sponsors
Vice chancellor for research, Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Exclusion criteria: age 70 year, concomitant causes of liver disease, such as hepatitis B virus infection, autoimmunity and alcohol abuse (>40 g/day for men and >20 g/day for women), HIV infection, hepatocellular carcinoma, decompensated cirrhosis, severe concurrent disease, contraindications to treatment with vitamin B12. Inclusion criteria: age between 18 to70 years, Lack of concomitant causes of liver disease, such as hepatitis B virus infection, autoimmunity and alcohol abuse (>40 g/day for men and >20 g/day for women), Lack of HIV infection, Lack of hepatocellular carcinoma, Lack of decompensated cirrhosis, Lack of severe concurrent disease.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum viral load. Timepoint: before intervention, one month after intervention, end of intervention, 3 months after the end of intervention. Method of measurement: copy of virus in ml of serum. | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver enzymes. Timepoint: before intervention, one month after intervention, end of intervention, 3 months after the end of intervention. Method of measurement: miligram per deciliter of serum. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactGholam Reza Sivandzadeh
Gastroenterohepatology research center, Shiraz University of Medical Sciences
Outcome results
None listed