laparotomy. Disease of intestine, unspecified
Conditions
Interventions
Intervention 1: One hour before induction of anesthesia, 1 gram of intravenous vitamin C is administered to the patients in vitamin C group. Intervention 2: In the control group, the same volume of no
Treatment - Drugs
Placebo
One hour before induction of anesthesia, 1 gram of intravenous vitamin C is administered to the patients in vitamin C group.
In the control group, the same volume of normal saline, in the same color syringes is administered intravenously one hour before anesthesia induction.
Sponsors
Deputy of Research, Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
25 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: ASA class I,II; age between 25 to 70 years old; elective laparotomy; Exclusion criteria: severe disabling illness; Addison or Cushing disease; septic shock; severe sepsis; trauma; history of corticosteroid intake at a dose that could suppress cortico-pituitary-adrenal; duration of surgery longer than 4 hours; extreme changes in hemodynamics during surgery
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Free cortisol level. Timepoint: one sample 5 minutes before induction and another sample 4 hours after induction. Method of measurement: serum level of cortisol.;ACTH: Adrenocorticotropic hormone. Timepoint: one sample 5 minutes before induction and another sample 4 hours after induction. Method of measurement: serum level of ACTH (Adrenocorticotropic hormone). | — |
Secondary
| Measure | Time frame |
|---|---|
| Body mass index: BMI. Timepoint: at the start of study entry. Method of measurement: clinical files of the patients. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Dabbagh
Modarres Hospital, Shahid Beheshti University of Medical Sciences
Outcome results
None listed