Treatment of respiratory distress syndrome in preterm infants

Comparison of two methods of respiratory support: Nasal Continuous positive Airway Pressure (NCPAP) and Nasal Intemitant Positive Pressure Ventilation (NIPPV) after less invasive surfactant administration (LISA) in preterm infants 28 to 36 weeks of age with respiratory distress syndrome, a Randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20151123025202N9

Enrollment

Registered

2020-06-19

Start date

2020-01-15

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

neonatal respiratory distress syndrome. Respiratory distress syndrome of newborn

Interventions

Intervention 1: Intervention group: Nasal Intermittent Positive Pressure Ventilation (NIPPV) after less invasive surfactant administration (LISA). This group intermittently will expose to higher lev

Eligibility

Sex/Gender

All

Age

1 Days to 28 Days

Inclusion criteria

Inclusion criteria: gestational age of 28-37 weeks With distress syndrome Fraction of inspired oxygen>40 Require treatment with surfactant in less than 24 hours after birth

Exclusion criteria

Exclusion criteria: APGAR score<5 Suffering from any congenital disease

Design outcomes

Primary

Measure	Time frame
Respiratory support. Timepoint: First week of birth. Method of measurement: Investigation of FIO2 and analysis of arterial blood gases.	—

Secondary

Measure	Time frame
Hospitalization duration. Timepoint: From hospitalization to discharge. Method of measurement: Review of infant medical records.;Mortality. Timepoint: From hospitalization to discharge. Method of measurement: Review of infant medical records.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbbas Moradi

Hamedan University of Medical Sciences

a.moradi@umsha.ac.ir+98 81 3838 0097

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026