Traumatic brain injury. Diffuse traumatic brain injury with loss of consciousness of 30 minutes or less, initial encounter
Conditions
Interventions
Intervention 1: Intervention group: In addition to routine treatment for traumatic brain injury, they will receive amantadine 200 mg twice daily (oral or via a feeding tube) for 8 weeks. Intervention
Sponsors
Hamedan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients with acute brain injury Glasgow Coma Scale score of 9 to 12 in the first 24 hours of injury Having post-traumatic amnesia and immediately after the accident Having at least mild diffuse axonal damage Age 18 to 75 years
Exclusion criteria
Exclusion criteria: People with a history of underlying cognitive and memory impairment Any central nervous system-related disability that existed before the traumatic brain injury Pregnant women Serious kidney disease (estimated creatinine clearance less than 60 ml/min), Patient with a history of more than one seizure in the previous month History of previous treatment with amantadine and sensitivity to amantadine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in cognitive function in the two domains of return to life and ability to take care of oneself. Timepoint: Before treatment and 8 weeks after treatment. Method of measurement: Dementia Rating Scale (DRS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Possible side effects of amantadine treatment. Timepoint: From the beginning of treatment to the end of treatment. Method of measurement: Clinical examination and telephone follow-up. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAbbas Moradi
Hamedan University of Medical Sciences
Outcome results
None listed