Acne Treatment with N-Acetylcysteine Gel

Investigating the effect of topical N Acetylcystein%5 on mild to moderate Acne Vulgaris: a double blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20151123025202N48

Enrollment

146

Registered

2025-10-07

Start date

2025-10-23

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne Vulgaris. Acne vulgaris

Interventions

Intervention 1: Intervention group: will be treated with topical 5% N-acetylcysteine ??gel and topical clindamycin. Intervention 2: Control group: They will receive placebo (base gel without N-acetylc

Eligibility

Sex/Gender

All

Age

12 Years to 30 Years

Inclusion criteria

Inclusion criteria: Patients with mild to moderate facial acne vulgaris Age 12–30 years Lesion count: 20–100 inflammatory/non-inflammatory lesions No systemic or topical acne treatments in the past 3 months

Exclusion criteria

Exclusion criteria: Pregnancy or lactation History of treatment-resistant acne. Other acne subtypes (e.g., conglobata) Having underlying medical conditions such as diabetes or thyroid disorders

Design outcomes

Primary

Measure	Time frame
Changes in acne severity. Timepoint: Before treatment, end of week 3, 6, and 8 after treatment. Method of measurement: Global Acne Grading System (GAGS).	—

Secondary

Measure	Time frame
Treatment complications. Timepoint: From the start of treatment to the end of the eighth week. Method of measurement: Questioning the patient.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbbas Moradi

Hamedan University of Medical Sciences

a.moradi@umsha.ac.ir+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026