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Investigating the anti-headache effects of metoclopramide and acetaminophen in comparison with metoclopramide and placebo

Comparison of the analgesic effect of metoclopramide and acetaminophen with metoclopramide and placebo in the management of acute migraine headache

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20151123025202N37
Enrollment
88
Registered
2024-04-19
Start date
2024-05-04
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute migraine headache. Other headache syndromes

Interventions

Intervention 1: Intervention group: First, they will receive 2 cc (equivalent to 10 mg) of metoclopramide intraserum. Then, one gram of intravenous acetaminophen (equivalent to 7 cc) along with 100 cc

Sponsors

Hamedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: The presence of migraine criteria according to the classification of the International Headache Society Headache pattern consistent with migraine and previous attack

Exclusion criteria

Exclusion criteria: History of allergy to metoclopramide or acetaminophen History of liver, renal and heart failure, malignancy Pregnancy and breastfeeding History of gastrointestinal obstruction or gastrointestinal bleeding or clinical suspicion of either Trauma, seizure or abnormal neurological examination Smoking or drug use High systolic and diastolic blood pressure

Design outcomes

Primary

MeasureTime frame
Headache Severity. Timepoint: Before treatment, 15 minutes and 30 minutes after treatment. Method of measurement: Visual Analogue Scale (VAS).

Secondary

MeasureTime frame
Need for additional analgesic. Timepoint: 60 minutes after treatment onset. Method of measurement: Extracting on patient's medical record.;Complications, nausea, vomiting, blurred vision, drowsiness and restlessness. Timepoint: Within an hour after treatment. Method of measurement: by asking the patients.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbbas Moradi

Hamedan University of Medical Sciences

a.moradi@umsha.ac.ir+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026