Major neurocognitive disorder. Dementia in other diseases classified elsewhere
Conditions
Interventions
Intervention 1: Intervention group: In the intervention group of vascular risk factors management intervention, those who need medication for physical problems will be treated with medication. For tho
Sponsors
Department of health and ageing - Department of population, family and school health
Eligibility
Sex/Gender
All
Age
55 Years to 74 Years
Inclusion criteria
Inclusion criteria: Aged 55 to 74 years. Having at least one modifiable dementia risk factor from among hypertension, diabetes mellitus, dyslipidemia, obesity, abdominal obesity, abdominal obesity, metabolic syndrome, smoking, educational level less than 9 years, physical inactivity, and social inactivity. No neurocognitive disorder detected by the psychiatrist with the use of DSM5 criteria at the base time. The score 85 or more in the Addenbrooke cognitive test at the base time. Able to independently perform the activities of daily living. Can read and write in Farsi. Able to participate in the exercise program safely. Having a reliable informant who can provide investigators with requested information. Providing written informed consent.
Exclusion criteria
Exclusion criteria: Existence of major psychiatric illness such as major depressive disorder. Existence of other neurodegeneration disease such as Parkinson's disease. The history of malignancy within the previous 5 years. The history of cardiac stent or revascularization within the previous 1 year. Existence of serious or unstable medical disease such as acute or sever asthma, active gastric ulcer, sever liver disease, or sever renal disease. Existence of sever loss of vision or hearing, or communication disability. Existence of any conditions preventing cooperation as judged by the study physician. Existence of significant laboratory abnormality that may result in cognitive impairment. The simultaneous participation in any other intervention trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Addenbrooke's Cognitive Examination Score. Timepoint: at the baseline, and the third and the sixth month after intervention. Method of measurement: Addenbrooke's Cognitive Examination-II Score.;Cambridge Neuropsychological Test Automated Battery. Timepoint: At the baseline, the third and the sixth month after intervention. Method of measurement: CANTAB Cognitive Software. | — |
Secondary
| Measure | Time frame |
|---|---|
| Barthel Index of Activities of Daily Living Score. Timepoint: At the baseline time, and the third and the sixth month after the start of intervention. Method of measurement: Barthel Index of Activities of Daily Living Questionnaire.;Lawton instrumental activity of daily living diary Score. Timepoint: At the baseline time, and the third and the sixth month after the start of intervention. Method of measurement: Lawton instrumental activity of daily living diary Questionnaire.;Short Physical Performance Battery Scale Score. Timepoint: At the baseline time, and the third and the sixth month after the start of intervention. Method of measurement: Short Physical Performance Battery Scale Questionnaire.;Food Frequency Questionnaire Score. Timepoint: At the baseline time, and the third and the sixth month after the start of intervention. Method of measurement: Food Frequency Questionnaire.;A Three Day Food Record Score. Timepoint: At the baseline time, and the third and the sixth month after the start of intervention. Method of measurement: A Three Day Food Record Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBehnam Shariati
Iran University of Medical Sciences
Outcome results
None listed