Heart failure.
Conditions
Interventions
Using 600 mg allopurinol daily for 3 months.
Treatment - Drugs
Using 600 mg allopurinol daily for 3 months
Sponsors
Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Age of 18-80 years old; severe left ventricle systolic dysfunction (Ejection fraction of less than 35%) on optimal medical treatment for at least one month with New York heart association functional class of II-III; having informed written consent. Exclusion criteria: Below the age of 18 and above the age of 80 years old; glomerular filtration rate of less than 60ml/min; serum creatinine level of more than 3mg/dl; severe hepatic failure; use of azathioprin; use of 6mercaptopurin; use of warfarin; known history of sensitivity to allopurinol.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ProBNP. Timepoint: 3 month. Method of measurement: Laboratory kit.;6 minute walk test. Timepoint: 3 month. Method of measurement: Rehabilitation department of the center.;Strain echocardiography. Timepoint: 3 month. Method of measurement: Vivid 6s echocardiography system.;Quality of life of the patients. Timepoint: 3 month. Method of measurement: IHF-QoL. | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin rash. Timepoint: during the 3 months. Method of measurement: Medical history and physical exam.;Gastrointestinal compliations. Timepoint: during the 3 months. Method of measurement: Medical history and physical exam. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Mostafa Ansari-Ramandi
Rajaie Cardiovascular Medical and Research Center. Tehran, Iran
Outcome results
None listed