comparison of Adaptive Support Ventilation (ASV) and Synchronized Intermittent Mandatory Ventilation (SIMV) modes

The comparison of respiratory parameters in mechanical ventilation with Adaptive Support Ventilation (ASV) and Synchronized Intermittent Mandatory Ventilation (SIMV) in the hospitalized neurosurgical patients in ICU

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015112016151N3

Enrollment

Registered

2015-11-28

Start date

2015-08-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mechanical ventilation. Other specified medical care

Interventions

Intervention 1: Intervention group 1: sedation will be done for patients (with propofol 1-2 mg/kg/h) if they need. Patients will be given 1 mg midazolam (bolus) if they can’t tolerate the tracheal tub

Treatment - Devices

Intervention group 1: sedation will be done for patients (with propofol 1-2 mg/kg/h) if they need. Patients will be given 1 mg midazolam (bolus) if they can’t tolerate the tracheal tube (to be in Rams

Intervention group 2: sedation will be done for patients (with propofol 1-2 mg/kg/h) if they need. Patients will be given 1 mg midazolam (bolus) if they can’t tolerate the tracheal tube (to be in Rams

Eligibility

Sex/Gender

All

Age

No minimum to 100 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: hospitalized in neurosurgery ICU; decreased consciousness; need to intubation and mechanical ventilation; no respiratory failure. Exclusion criteria: severe liver failure (ascites, abnormal liver function tests); severe liver and renal failure ; severe lung disease based on PFT (FEV130); pregnancy; smoking; respiratory failure (MAP38, PH50, PO2<60 with FiO2<0.6); involvement or lesion of brain stem.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Peak airway pressure. Timepoint: minutes 10,20,30. Method of measurement: cm H2O by ventilator.;Static lung compliance. Timepoint: 30 minutes after intervention. Method of measurement: ml/cm H20 by ventilator.;Dynamic lung compliance. Timepoint: 30 minutes after intervention. Method of measurement: ml/cm H20 by ventilator.	—

Secondary

Measure	Time frame
Arterial CO2. Timepoint: minutes 10,20,30. Method of measurement: mmHg by ABG.;Arterial oxygen presuure. Timepoint: minutes 10,20,30. Method of measurement: mmHg by ABG.;Respiratory rate. Timepoint: minutes 10,20,30. Method of measurement: rate in minute.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Alireza Pournajafian

Iran University of Medical Sciences

alipn78@yahoo.com; pournajafian.ar@iums.ac.ir+98 21 8894 6762

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026