Effect of oral mixture of midazolam and ketamin with oral mixture of meperidine and chloral hydrate on calmness and post operative pain in pediatric tonsillectomy surgery.

Comparison the effect of oral mixture of midazolam and ketamin with oral mixture of meperidine and cholral hydrate in agitation and post operative pain in pediatric patients undergoing tonsillectomy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015111611662N8

Enrollment

Registered

2015-12-17

Start date

2015-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain following tonsillectomy. Pain in throat

Interventions

Intervention 1: In the group one pediatrics will be received oral mixture midazolam and ketamine mg/kg 30 min before going to operation room. Intervention 2: in the 2nd group pediatrics will be recei

Treatment - Drugs

In the group one pediatrics will be received oral mixture midazolam and ketamine mg/kg 30 min before going to operation room.

in the 2nd group pediatrics will be received oral mixture of meperidine mg/kg and chloral hydrate mg/kg 30 min before operation

Eligibility

Sex/Gender

All

Age

3 Years to 8 Years

Inclusion criteria

Inclusion criteria: 64 pediatrics patients who will be candidate for elective tonsillectomy under general anesthesia will be enrolled in this study. Exclusion criteria are: emergency surgery; history of cardiopulmonary disorders; hypersensitivity to study's drugs; liver disease; kidney disease and history of convulsion.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Post operative pain. Timepoint: Every hour during first 6 hours post operation. Method of measurement: Backer-Wong-faces pain scale.;Postoperative agitation. Timepoint: after awakening in recovery room. Method of measurement: according to this scale: 1.Asleep ;2. Awake but comfort ;3.Agitate ; 4.severly agitate and difficult to calm.;Calmness during going to operatin theater. Timepoint: During seperation from parents and going to operation theater. Method of measurement: according to this scale: 1.Full awake-calm ; 2. crying ; 3. violent movement ; 4. Asleep.	—

Measure

Time frame

Post operative pain. Timepoint: Every hour during first 6 hours post operation. Method of measurement: Backer-Wong-faces pain scale.;Postoperative agitation. Timepoint: after awakening in recovery room. Method of measurement: according to this scale: 1.Asleep ;2. Awake but comfort ;3.Agitate ; 4.severly agitate and difficult to calm.;Calmness during going to operatin theater. Timepoint: During seperation from parents and going to operation theater. Method of measurement: according to this scale: 1.Full awake-calm ; 2. crying ; 3. violent movement ; 4. Asleep.

—

Secondary

Measure	Time frame
Nausea and Vomiting. Timepoint: Every one hour during first postoperative 6 hr. Method of measurement: Nausea is defined as urge to vomiting without ejection ofof the contents of the stomach through the mouth, Vomiting is defined asto eject of the contents of the stomach through the mouth, usually in a series of involuntary spasmic movements.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Ali Sahmeddini

Shiraz University Of Medical Sciences

sahmeddini@sums.ac.ir+98 71 3647 4270

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026