Effects of Supplementation with vitamin D on anti aging protein klotho

Effects of Supplementation with vitamin D on anti aging protein klotho in old people

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201511152709N36

Enrollment

Registered

2016-02-18

Start date

2015-12-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vitamin d deficiency. Vitamin D deficiency, unspecified

Interventions

Intervention 1: Intervention group: receive 50000IU vitamin D weekly , for 12 weeks. Intervention 2: Control group: receive vitamin D placebo weekly , for 12 weeks.

Treatment - Other

Placebo

Intervention group: receive 50000IU vitamin D weekly , for 12 weeks.

Control group: receive vitamin D placebo weekly , for 12 weeks.

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria: more than 60 years old; old people with deficiency or insufficiency of serum Vitamin D levels (less than 30ng/ml serum 25-hydroxyvitamin D); Willingness to cooperate in the study; Lack of sensitivity to Vitamin D Supplement; no Consumption of multi vitamin, mineral and omega 3 Supplement; no Consumption of Vitamin D Supplement; Non-diabetic people; Without a history of stroke or Severe card

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Serum soluble klotho. Timepoint: before and after intervention. Method of measurement: ELISA.;25(OH)D. Timepoint: before and after intervention. Method of measurement: ELISA.;1,25(OH)2D. Timepoint: before and after intervention. Method of measurement: ELISA.;FBS. Timepoint: before and after intervention. Method of measurement: Colorimetric.;HgA1c. Timepoint: before and after intervention. Method of measurement: Ion exchange.;Hs-CRP. Timepoint: before and after intervention. Method of measurement: ELISA.;Super Oxide Dismutase assay. Timepoint: before and after intervention. Method of measurement: Calorimetry.;Cognitive function. Timepoint: before and after intervention. Method of measurement: questionnaire.	—

Measure

Time frame

Serum soluble klotho. Timepoint: before and after intervention. Method of measurement: ELISA.;25(OH)D. Timepoint: before and after intervention. Method of measurement: ELISA.;1,25(OH)2D. Timepoint: before and after intervention. Method of measurement: ELISA.;FBS. Timepoint: before and after intervention. Method of measurement: Colorimetric.;HgA1c. Timepoint: before and after intervention. Method of measurement: Ion exchange.;Hs-CRP. Timepoint: before and after intervention. Method of measurement: ELISA.;Super Oxide Dismutase assay. Timepoint: before and after intervention. Method of measurement: Calorimetry.;Cognitive function. Timepoint: before and after intervention. Method of measurement: questionnaire.

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Secondary

Measure	Time frame
Blood pressure. Timepoint: Before and after intervention. Method of measurement: Mercury sphygmomanometer.;Weight. Timepoint: before and after intervention. Method of measurement: Digital scale.;Dietary intake. Timepoint: before and after intervention. Method of measurement: questionare.;Body mass index. Timepoint: before and after intervention. Method of measurement: Calculation.;Physical activity. Timepoint: before and after intervention. Method of measurement: questionare.;Sun exposure. Timepoint: before and after intervention. Method of measurement: questionare.;Drug consumption. Timepoint: before and after intervention. Method of measurement: questionare.;Smoking. Timepoint: before and after intervention. Method of measurement: questionare.	—

Measure

Time frame

Blood pressure. Timepoint: Before and after intervention. Method of measurement: Mercury sphygmomanometer.;Weight. Timepoint: before and after intervention. Method of measurement: Digital scale.;Dietary intake. Timepoint: before and after intervention. Method of measurement: questionare.;Body mass index. Timepoint: before and after intervention. Method of measurement: Calculation.;Physical activity. Timepoint: before and after intervention. Method of measurement: questionare.;Sun exposure. Timepoint: before and after intervention. Method of measurement: questionare.;Drug consumption. Timepoint: before and after intervention. Method of measurement: questionare.;Smoking. Timepoint: before and after intervention. Method of measurement: questionare.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarzad Shidfar

Iran University of medical science

: farzadshidfar@yahoo.com+98 21 8862 2755

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026