Rheumatoid arthritis. Seropositive rheumatoid arthritis
Conditions
Interventions
Intervention 1: For twelve weeks, patients treated with Pioglitazone pills, daily 30 mg in intervention group. Intervention 2: For twelve weeks use Pioglitazone pills that filled with starch as placeb
Treatment - Drugs
Placebo
For twelve weeks, patients treated with Pioglitazone pills, daily 30 mg in intervention group
For twelve weeks use Pioglitazone pills that filled with starch as placebo in control group
Sponsors
Vice Chancellor for research of Arak University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age between 20-65 years old; patients with rheumatoid arthritis (ACR) criteria; disease activity based on DAS-28> 3.2; signed informed consent. Exclusion criteria: comorbidities such as diabetes mellitus, kidney and liver diseases, etc; severe obesity (BMI> 35); uncontrolled hypertension; congestive heart failure (CHF); side effects of pioglitazone drug; acute and active infectious disease; hyperlipidemia TG> 200, total cholestal> 220; indicated to biological drugs.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease Activity Score (DAS-28). Timepoint: before and twelve weeks after intervention. Method of measurement: by means of DAS-28 validated questionnaire.;The number of painful and swollen joints. Timepoint: before and twelve weeks after intervention. Method of measurement: visual scale.;Tests (ESR-hs CRP-Cholesterol-HDL-TG-BUN-Cr-AST-ALT-ALK-P). Timepoint: before and twelve weeks after intervention. Method of measurement: Laboratory Kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Talaat Shahmoradi
Arak University of Medical Sciences
Outcome results
None listed