COVID-19. corona virus disease 2019
Conditions
Interventions
Intervention 1: Intervention group: Discontinuation of agents inhibiting renin-angiotensin-aldosterone system substituting by calcium channel blocker with or without beta-blocker. Intervention 2: Cont
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients who have suggestive signs of COVID-19 in their chest computed tomography scan, reported by a radiologist Patients consuming angiotensin converting enzyme-inhibitors or angiotensin receptor blocker
Exclusion criteria
Exclusion criteria: Uncontrolled hypertension with systolic blood pressure more than 180 or diastolic more than 120 Past history of congested heart failure or arrhythmia with various severity Sensitivity to the newly-prescribed medications History of severe asthma History of known depression Consuming medications with interactions such as lithium, antiepileptic drugs, chemotherapy Pregnancy Patient unwillingness to enter the study Patients whose prognosis is influenced by another disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Death. Timepoint: 3 months. Method of measurement: Number of deceased patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU admission. Timepoint: 6 months. Method of measurement: Number of deceased patients. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Bahreini
Tehran University of Medical Sciences
Outcome results
None listed