In vitro fertilization. Admission for harvesting or implantation of ova
Conditions
Interventions
Intervention 1: Intervention group: Gelatin capsule of vitamin D, 50000 units, orally, once a week, for 6 weeks. Intervention 2: Control group: Placebo, Gelatin capsule, orally, once a week, for 6 wee
Treatment - Drugs
Placebo
Intervention group: Gelatin capsule of vitamin D, 50000 units, orally, once a week, for 6 weeks.
Control group: Placebo, Gelatin capsule, orally, once a week, for 6 weeks.
Sponsors
Vice Chancellor for Research of Nursing and Midwifery Faculty, Isfahan University of Medical Science
Eligibility
Sex/Gender
Female
Age
18 Years to 38 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Women in the age of 18 to 38 years ; having Primary infertility ; having female infertility approved by gynecologist ; using of long-term down-regulation protocol and then ovulation induction ; not using of vitamin D supplementation before the study ; not having a medical history of systemic disorders such as Cushing's syndrome, hyper or hypothyroidism, hyperprolactimenia ; no liver, kidney and heart diseases ; having BMI Less than or equal to 30 KG/M2 or More than or equal to 18.9 KG/M2 ; not having clinical signs of vitamin D deficiency such as osteomalacia, osteoarthritis, the joint and bone pain and rheumatoid arthritis ; not using of drugs such as Phenytoin, Phenobarbital, Carbamazepine, Isoniazid, Rifampin Theophylline which may affect on vitamin D metabolism ; the absence of congenital or acquired uterine defects ; not having endometriosis. Exclusion criteria: Using surrogate uterine ; using the Oocyte donation ; Unwillingness to continue cooperation ; not having fertile follicle after injection of gonadotropin hormone.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of clinical pregnancy. Timepoint: Four weeks after intervention. Method of measurement: Ultrasound.;Rate Biochemical pregnancy. Timepoint: 7 days after embryo transfer. Method of measurement: Laboratory Kit.;Rate of fertilization. Timepoint: 16 to 18 hours after in vitro fertilization. Method of measurement: Microscope.;Embryo quality. Timepoint: 16 to 18 hours after in vitro fertilization. Method of measurement: Microscope.;Endometrial quality. Timepoint: At the same time oocyte retrieval. Method of measurement: Ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of oocytes. Timepoint: WHEN PICK UP. Method of measurement: Microscope.;Vitamin D serum after intervention. Timepoint: 6 to 8 weeks after intervention. Method of measurement: Laboratory Kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahboubeh Taebi
Nursing and Midwifery faculty of Isfahan
Outcome results
None listed