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Effect of Zinc in improvement of Aphthous

Evaluation of the effectiveness of Zinc Sulfate mucoadhesive tablet in the improvement of Recurrent Aphthous Stomatitis (RAS)

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20151109024975N9
Enrollment
46
Registered
2018-08-01
Start date
2018-01-21
Completion date
Unknown
Last updated
2018-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recurrent Aphthous Stomoatitis. Recurrent oral aphthae

Interventions

Intervention 1: Intervention group: Patients received mucoadhesive tablets three times a day containing Zinc Sulfate (morning, afternoon and night). How to use the mucoadhesive tablets was taught to

Sponsors

Sari University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 45 Years

Inclusion criteria

Inclusion criteria: Individuals with adequate knowledge and literacy Age group is 16 to 45 years old Aphthous diagnostic criteria Ability to fill out the consent form legally

Exclusion criteria

Exclusion criteria: Individuals with major recurrent aphthous stomatitis & herpetic form Patients who had aphthous lesions in other areas than Labial & Buccal mucosa Patients with systemic disease during last month Patients with Denture Patients consuming antibiotics Patients with pregnancy Individuals with poor oral hygiene Individuals who are not capable of receiving Zinc sulfate mucoadhesive Individuals who have syndromes which Aphthous ulcers are one the manifestations, like Behcet's syndrome Individuals who are prescribed a non-Zinc drug for Aphthous improvement Smoking Individuals Individuals who consume Immunosuppressive drug during last month Individuals who couldn't resume the study according to social or personal issues

Design outcomes

Primary

MeasureTime frame
Diameter of eritmathous halo. Timepoint: Zero (before entering the study); third; fifth and seventh days. Method of measurement: Metal caliber.

Secondary

MeasureTime frame
Period of improvement. Timepoint: Zero (before entering the study); third; fifth and seventh days. Method of measurement: Visual Analogue Scale Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAnahita Ghorbani

Sari University of Medical Sciences

anahita1802@yahoo.com+98 11 3304 4001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 18, 2026