Comparison of dexmedetomidine with propofol in maintaining adequate depth of anesthesia

Comparison of dexmedetomidine as a main anastasia drug with propofol on maintain sufficient depth of anesthesia in patients undergoing elective laparotomy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20151107024909N12

Enrollment

Registered

2022-10-30

Start date

2022-11-06

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia. Anaesthetic, unspecified

Interventions

Intervention 1: Intervention group: Induction included midazolam 0.03 mg/kg (Manufacturing factory: Abu Rayhan), fentanyl 2 mg/kg (manufacturer: Norman SA), propofol 1-2 mg/kg (manufacturer: Bran B),

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients over 20 years Patients who are candidates for laparotomy surgery Surgery with a time of more than 3 hours under general anesthesia

Exclusion criteria

Exclusion criteria: Patients over 60 years Emergency surgery Contraindications to the use of dexmedetomidine Pregnancy or breastfeeding Drug addiction Uncontrolled blood pressure Body mass index above 30

Design outcomes

Primary

Measure	Time frame
Depth of anesthesia. Timepoint: At the beginning and during surgery. Method of measurement: Anesthesia depth monitoring device.;Pain level of patients. Timepoint: From the beginning of recovery every 15 minutes up to three times. Method of measurement: Visual analog scale.;Agitation score. Timepoint: From the beginning of recovery every 15 minutes up to three times. Method of measurement: Based on the information in the patient's file.;Sedition score. Timepoint: From the beginning of recovery every 15 minutes up to three times. Method of measurement: Based on the information in the patient's file.	—

Measure

Time frame

Depth of anesthesia. Timepoint: At the beginning and during surgery. Method of measurement: Anesthesia depth monitoring device.;Pain level of patients. Timepoint: From the beginning of recovery every 15 minutes up to three times. Method of measurement: Visual analog scale.;Agitation score. Timepoint: From the beginning of recovery every 15 minutes up to three times. Method of measurement: Based on the information in the patient's file.;Sedition score. Timepoint: From the beginning of recovery every 15 minutes up to three times. Method of measurement: Based on the information in the patient's file.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFaranak Rokhtabnak

Iran University of Medical Sciences

rolhtabnak.f@iums.ac.ir+98 21 6640 6761

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026