comparison of anesthetic effect between lidocaine and articain

Comparison of pain perception and onset time of anesthesia between lidocaeine and articaine for local anesthesia of the maxillary central incisor in healthy subjects: a randomized, double blind crossover trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015110613932N3

Enrollment

Registered

2016-06-19

Start date

2016-02-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

local anesthesia. Local anaesthetics

Interventions

Intervention 1: Infiltrative injection of 2% lidocaine carpule with epinephrine 1:100000 and measuring of pain perception at the time of injection by using visual analogue pain scale and onset time of

Treatment - Drugs

Infiltrative injection of 2% lidocaine carpule with epinephrine 1:100000 and measuring of pain perception at the time of injection by using visual analogue pain scale and onset time of anesthesia in o

Infiltrative injection of 4% articaine carpule with epinephrine 1:100000 and measuring of pain perception at the time of injection by using visual analogue pain scale and onset time of anesthesia in o

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: healthy volunteers with intact maxillary central incisor that response to pulp tester; individuals who can use visual analogue pain scale Exclusion criteria: patients with periodontal disease; positive history of alcohol consumption; cigarette smoking; drug user; patients who have received antidepressant or steroid analogues drug during the 48 hours before study; pregnant patients; patients with known allergy to lidocaine or epinephrine; peripheral neuropathy, positive history of dental phobia or any damage to teeth

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Onset time of anesthesia. Timepoint: 1 minute intervals. Method of measurement: Electric Pulp Test.;Severity of pain during injection. Timepoint: Immediately after the injection. Method of measurement: Visual analogue pain scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRokhsare Zare Shahri

Student Research Committee

mahtab_137@yahoo.com+98 76 3333 0521

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026