Efficacy of frequent high dose dexamethasone in treatment of primary immune thrombocytopenic purpura

Comparison between efficacy of multiple courses of high-dose dexamethasone therapy and single course of high dose dexamethasone in the treatment of newly diagnosed primary immune thrombocytopenia

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015110424881N1

Enrollment

Registered

2016-07-02

Start date

2014-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Newly diagnosed immune thrombocytopenic purpura. Immune thrombocytopenic purpura

Interventions

Intervention 1: Intervention: The group of patients who received 4-6 courses of high dose dexamethasone every 14 days. Intervention 2: Control: The group of patients who received single course of dexa

Treatment - Drugs

Intervention: The group of patients who received 4-6 courses of high dose dexamethasone every 14 days

Control: The group of patients who received single course of dexamethasone plus oral prednisolone

Eligibility

Sex/Gender

All

Age

15 Years to 100 Years

Inclusion criteria

Inclusion criteria: All Primary and newly diagnosed immune thrombocytopenic purpura patients enrolled the study. Inclusion criteria: Platelet count less than 20000; platelet count more than 20000 in cases with bleeding. Exclusion criteria: comorbidities such as diabetes; liver or renal disease; HIV; Previous history of immune thrombocytopenic purpura; recently use of steroids; history of systemic lupus erythmatous; No consent (declining) for participating in study

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Platelet count. Timepoint: Monthly till 12 months after treatment course. Method of measurement: Cell Blood Count; Platelet count.	—

Secondary

Measure	Time frame
Blood pressure. Timepoint: Monthly after treatment and every 15 min during dexamethasone courses. Method of measurement: By manometer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Sepehri

Zabol University of Medical Sciences

Sepehri_za@zbmu.ac.ir+98 54 3223 0768

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026