Melasma. Chloasma
Conditions
Interventions
Intervention 1: In the first group: After using of topical anesthesia at the injection site ( lidocaine cream 60 minutes before injection), Tranexamic acid ampoule intradermaly is injected into the m
Treatment - Drugs
In the first group: After using of topical anesthesia at the injection site ( lidocaine cream 60 minutes before injection), Tranexamic acid ampoule intradermaly is injected into the melasma lesions w
In the second group: About the amount of the usage of Hydroquinon 4% cream we use Finger Tip Unit indicator and the maximum dose in every usage is 1 gr. Treatment period is 12 weeks. Assessment of r
Sponsors
Vice-Chancellor in Research Affairs of Shahid Beheshti University of Medical Science
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Every patient between 20-50 years old that do not use any topical treatment for melasma at least 1 month before the trial and have epidermal melasma with wood 's lamp and do not have exclusion criteria. Exclusion criteria: Pregnancy and lactation; Dermal melasma; Using any treatment for melasma during 1 month ago; Using OCP or any hormonal or phototoxic drugs.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hyperpigmentation homogeneity. Timepoint: Before intervention,4 weeks and 8 weeks after begining of the intervention and 4 weeks ater the end of the intervention. Method of measurement: MASI score.;Area involved. Timepoint: before intervention,4weeks and 8 weeks after begining of the intervention and 4 weeks ater the end of the intervention. Method of measurement: MASI score.;Darkness of pigment compared with normal skin. Timepoint: before intervention,4weeks and 8 weeks after begining of the intervention and 4 weeks ater the end of the intervention. Method of measurement: MASI score. | — |
Secondary
| Measure | Time frame |
|---|---|
| Erythema. Timepoint: 4 weeks and 8 weeks after beginning of the intervention and 4 weeks after the end of the intervention. Method of measurement: Asking the patient.;Irritation. Timepoint: 4 weeks and 8 weeks after beginning of the intervention and 4 weeks after the end of the intervention. Method of measurement: asking the patient.;Dryness. Timepoint: 4 weeks and 8 weeks after beginning of the intervention and 4 weeks after the end of the intervention. Method of measurement: Asking the patient.;Alergic reaction. Timepoint: 4 weeks and 8 weeks after beginning of the intervention and 4 weeks after the end of the intervention. Method of measurement: Asking the patient. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBita Saghi
Skin Research Center
Outcome results
None listed