obsessive compulsive disorder. Obsessive-compulsive disorder
Conditions
Interventions
Intervention 1: Intervention group with active drug
Memantine, 20 mg tablets
one per day for 8 weeks. Intervention 2: control group
placebo tablets, one per day for 8 weeks.
Treatment - Drugs
Placebo
Intervention group with active drug
Memantine, 20 mg tablets
one per day for 8 weeks
control group
placebo tablets, one per day for 8 weeks
Sponsors
Deputy of research and technology developement
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients with known obsessive compulsive disorder by DSM-V criteria; no other mental disorder; no other systemic disorder such as diabetes,hypertension,hyper and hypo thyroidism ;no alcohol intake and not a drug user; between 18 to 40 years old; the patient should be treated for at least 3 months with an antidepressant at highest dose and have a score of 21 or more in Yale-Brown Obsessive Compulsive Scale test. exclusion criteria:Pregnancy and nursing; Patients with a history of memantine use; Patients who do not sign the consent form.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient's score in Y-BOCS test. Timepoint: before intervention and 8 weeks after the treatment. Method of measurement: Y-BOCS test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: every week for 8 weeks of giving drug or placebo. Method of measurement: the list of memantine adverse effects. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSetareh Razooghi
Pharmacy school
Outcome results
None listed