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The effect of alfalfa seed on the treatment of male idiopathic infertility

Effect of Alfalfa (Medicago sativa) seed plus vitamin E on Spermogram Parameters in Men with Idiopathic infertility Compared to Vitamin E; A double blind clinical trial study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20151102024825N2
Enrollment
60
Registered
2019-07-25
Start date
2019-08-06
Completion date
Unknown
Last updated
2021-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spermogram Parameters in Men with Idiopathic Infertility. Male infertility

Interventions

Intervention 1: Intervention group: The sachet contains alfalfa seed powder .The dose is 6 grams per day, and each sachet contains 3 grams, which consumes the patient twice a day .Duration of use is t

Sponsors

Babol University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Men aged 20-45 with at least one year of idiopathic infertility There is at least one of the three criteria for sperm disorder (number-movement-morphology-volume of semen)The presence of idiopathic oligo-spasm disorders based on WHO criteria. The presence of sperm count is less than 15 million per ml and in general less than 39 million is called in the oligo-spermic semen.The presence of idiopathic osteonospermia disorder based on WHO criteria (if the percentage of normal sperm motility in semen is less than 40%) is called astenospermia.The presence of idiopathic teratospasm disorders based on WHO criteria (if the percentage of spermatozoa with normal morphology in semen is less than 4% is called teratospasm) Patient Satisfaction

Exclusion criteria

Exclusion criteria: 1. There is severe oligospermia or azoospermia (sperm count less than 5 million per ml) An Overview of Epididymal Prostatitis - Troma-Thoracic Tesules - Surgeries in the Iygoeno Scrotal Region Presence of a Pretesticular Disorder, such as Endocrine Disorders (Hyperprolactinemia, Congenital Adrenal Hyperplasia, ...) There are chromosomal abnormalities such as macrodilution in the chromosome y, and such as Klein Fletcher, Men XX, XYY The presence of a known Testicular disorder such as varicocele or orchitis or cryptorchidism There is a known post-testicular disorder, such as mechanical obstruction, impaired sperm transmission, or functional cavity obstruction, vasectomy ...... There is a history of receiving a drug for the treatment of infertility in the last three months There is a history of receiving medications that affect semen in the last three months Abnormal testosterone and gonadotropins and serum prolactin Abnormal thyroid hormones (Hypothyroidism or Hyperthyroidism) History of taking anti-metabolites and alkylating agents The history of cancer and chemotherapy and radiotherapy Cases of chronic diseases such as diabetes and cardiovascular disorders Genital tract infection Taking cytotoxic drugs, immunosuppressives, androgens or anti-androgens, alcohol and opioid use Liver failure Severe renal insufficiency BMI>=30kg/m2 Severe neurological and psychological illnesses (history of stroke) History of lupus or family history

Design outcomes

Primary

MeasureTime frame
Sperm motility. Timepoint: Before and after three months of medication. Method of measurement: spermogram.;Morphology sperm. Timepoint: Before and after three months of medication. Method of measurement: spermogram.;Sperm count. Timepoint: Before and after three months of medication. Method of measurement: spermogram.;Semen volume. Timepoint: Before and after three months of medication. Method of measurement: spermogram.

Secondary

MeasureTime frame
Evaluate possible side effects. Timepoint: Before and after taking alfalfa and vitamin E. Method of measurement: Drug Complaint Checklist.;The probable effect of the general temperament of patients in responding to treatment through standard questionnaires. Timepoint: Before giving the medication. Method of measurement: Standard Health Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzita Sadough

Babol University of Medical Sciences

a.sadough@mubabol.ac.ir+98 11 3219 4730

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026