sedative effect of propofol and ketofol on patients undergoingcoronary artery bypass graft (CABG)

comparison the sedative effect of propofol and ketofol on patients undergoing coronary artery bypass graft (CABG) in intensive care unit (ICU)

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201510314583N7

Enrollment

Registered

2016-08-20

Start date

2016-02-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischaemic heart diseases. Ischaemic heart diseases

Interventions

Intervention 1: intervention group 1: propofol 15 micro/kg/min once. Intervention 2: intervention group 2 : propofol 15 micro/kg/min plus ketamin 3 micro/kg/min once.

Treatment - Drugs

intervention group 1: propofol 15 micro/kg/min once

intervention group 2 : propofol 15 micro/kg/min plus ketamin 3 micro/kg/min once

Eligibility

Sex/Gender

All

Age

40 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients 40-60 years old with ASA 1,2 undergoing CABG in ICU in Afshar Hospital Exclusion criteria: patients requiring inotropic drugs; patients with impaired renal tests; addicted patients ; ejection fraction <40%; patients requiring hospitalization in the ICU for more than 24 hours; patients with known psychiatric problems; patients with history of seizure

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: each two hours after the beginning of the process. Method of measurement: according to Behavioral Pain Scale (Questionnaire).;Heart rate. Timepoint: every 30 minutes at the first four hours and then each one hour after that until extubation. Method of measurement: by monitoring.;Systolic blood pressure. Timepoint: every 30 minutes at the first four hours and then each one hour after that until extubation. Method of measurement: by monitoring.;Diastolic blood pressure. Timepoint: every 30 minutes at the first four hours and then each one hour after that until extubation. Method of measurement: by monitoring.;Mean arterial blood pressure. Timepoint: every 30 minutes at the first four hours and then each one hour after that until extubation. Method of measurement: by monitoring.;Patient sedation. Timepoint: once. Method of measurement: by Richmond scale (Questionnaire).	—

Measure

Time frame

Pain. Timepoint: each two hours after the beginning of the process. Method of measurement: according to Behavioral Pain Scale (Questionnaire).;Heart rate. Timepoint: every 30 minutes at the first four hours and then each one hour after that until extubation. Method of measurement: by monitoring.;Systolic blood pressure. Timepoint: every 30 minutes at the first four hours and then each one hour after that until extubation. Method of measurement: by monitoring.;Diastolic blood pressure. Timepoint: every 30 minutes at the first four hours and then each one hour after that until extubation. Method of measurement: by monitoring.;Mean arterial blood pressure. Timepoint: every 30 minutes at the first four hours and then each one hour after that until extubation. Method of measurement: by monitoring.;Patient sedation. Timepoint: once. Method of measurement: by Richmond scale (Questionnaire).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hossein Moshtaghion

Shahid Sadoughi University of Medical Sciences

moshtaghion@gmail.com+98 35 3822 4000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026