The effect of adding azithromycin to routine prophylactic regimen on the incidence of cesarean surgical site infection

Comparison between prophylactic cefazolin regimen with or without azithromycin on the incidence of cesarean site infection in Alzahra hospital of Tabriz

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201510265485N5

Enrollment

150

Registered

2015-12-06

Start date

2014-09-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: wound infection. Condition 2: post cesarian endometritis. Infected: caesarean section wound Other specified puerperal infections

Interventions

Intervention 1: Patient in control group will receive the routine prophylactic single dose of 1g cefazolin IV, after clamping umbilical cord. Intervention 2: 1g IV cefazolin after clamping umbilical

Prevention

Patient in control group will receive the routine prophylactic single dose of 1g cefazolin IV, after clamping umbilical cord.

1g IV cefazolin after clamping umbilical cord, plus 2 pills of azithromicin (250mg) from Keyhandaroo Company, Iran made, when they are able to intake by mouth.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criterion: women who underwent elective and non-elective Cesarian section. Exclusion criteria: immune deficiency; renal failure; women with two out of the four SIRS (systemic inflammatory response syndrome) criteria [ 1)body temperature above 38 or below 36 degree 2)pulse rate above 90 per minute 3)respiratory rate above 20 per minute 4)WBC above 12000 or below 4000]; hypersensitivity to cefazolin or azithromycin; patient receiving antibiotic in the past three months; diabetics.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Incidence of cesarean site wound infection. Timepoint: Before, in the current and immediately after, one day and ten day after the operation. Method of measurement: Vital sign and physical examination.;Incidence of endometritis. Timepoint: Before, in the current and immediately after, one day and ten day after the operation. Method of measurement: Vital sign and physical examination.	—

Secondary

Measure	Time frame
Cost. Timepoint: Ten day after discharge. Method of measurement: Rate of payment.;Duration of hospitalization. Timepoint: Ten day after operation. Method of measurement: Days of hospitalization.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNazli Navali

Tabriz University of Medical Sciences

navalin@tbzmed.ac.ir+98 41 3334 5416

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026