Nonalcoholic fatty liver disease (NAFLD). Nonalcoholic fatty liver disease (NAFLD
Conditions
Interventions
Intervention 1: Intervention:administration of vitamin D pearl and life style modification. Intervention 2: Control: lifestyle modification.
Treatment - Drugs
Lifestyle
Intervention:administration of vitamin D pearl and life style modification
Control: lifestyle modification
Sponsors
Vice Chancellor for Research Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion Criteria: ALT rising equals or more than 2times of normal level; probable diagnosis of Nonalcoholic Steatohepatitis and rule out of other hepatic-enzymes rising causes such as viral and autoimmune hepatitis; age more than 18 years; serum vitamin D level less than 30 nanogram per mililiter Exclusion Criteria: hepatic cirrhosis; pregnancy or breast-feeding; alcohol use ; substance abuse;vitamin D administration in 6 months ago, weight loss more than 5% in 1 year ago; newly-diagnosed diabetes (in the recent 1 year) which needs treatment: antioverweight medication ; hypercalcemia; chronic renal disease; life-threatening cardiopulmonary diseases ; hyperlipidemia which needs medication; medications which affect on hepatic enzymes
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The level of aminotransferases. Timepoint: 3th and 6th month. Method of measurement: biochemical.;Fibroscan and BMI. Timepoint: 3th and 6th month for BMI and 6th month for fibroscan. Method of measurement: fibroscan and anthropometric measurement( kg/m2). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactTarang Taghvaei
Mazandaran University of Medical Sciences
Outcome results
None listed