effects of hydrotherapy and massage on serum nerve growth factor and balance

The effects of hydrotherapy with and without massage on serum nerve growth factor and balance in diabetic neuropathy patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20151025024699N4

Enrollment

Registered

2019-10-26

Start date

2017-10-23

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetics patients with peripheral neuropathy. Type 2 diabetes mellitus

Interventions

Intervention 1: Intervention group: aerobic and resistance training in water for 1 hour/session, three times/week, for wight weeks Intervention. Intervention 2: Intervention group: massage for 30 min

Eligibility

Sex/Gender

All

Age

38 Years to 58 Years

Inclusion criteria

Inclusion criteria: Age of 38-58 Type 2 diabetics patients with peripheral neuropathy Sedentary and ability to walk a 1.6-km distance without assistance Interesting in participation in research No smoking No alcoholism Not taking supplements (including vitamins, minerals, ergogenic aids) Not participating in any regular training program for at least 6 months before the study. Taking metformin (500 mg, 2 times per day with meals) and glibenclamide (5 to 10 mg in the morning in a fasted state).

Exclusion criteria

Exclusion criteria: A history or evidence on physical examination of significant central nervous system dysfunction Significant musculoskeletal deformity Arthritis or pain that limits exercise. A history or clinical evidence of severe cardiovasculardiseases that limit the exercise A history or evidence on physical examination of vestibular dysfunction. A history of angina

Design outcomes

Primary

Measure	Time frame
Nerve growth factor. Timepoint: Before and 8 weeks after intervention. Method of measurement: ELISA.;Balance. Timepoint: Before and 8 weeks after intervention. Method of measurement: Berg Balance Scale.	—

Secondary

Measure	Time frame
Insulin. Timepoint: Before and 8 weeks after intervention. Method of measurement: ELISA.;Glucose. Timepoint: Before and 8 weeks after intervention. Method of measurement: Enzymatic method.;HBA1C. Timepoint: Before and 8 weeks after intervention. Method of measurement: Enzymatic method.;Body fat. Timepoint: Before and 8 weeks after intervention. Method of measurement: Body fat Analyzer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Bagheri

Ferdowsi University of Mashhad

will.fivb@yahoo.com+98 51 3521 4043

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026