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Letrozole in increasing endometrial thickness in Premenopausal patient

Comparison of the effect of Letrozole and medroxy progesterone on premenopausal patient with endometrial hyperplasia: Randomized Clinical Trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT201510244339N12
Enrollment
80
Registered
2015-12-04
Start date
2012-04-27
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometrial hyperplasia. Endometrial glandular hyperplasia

Interventions

Intervention 1: Control group (40 patients) received 10 mg of medroxy progesterone from day 16 to 25 three-months. The patients were rechecked up after three and six months. Also Transvaginal sonograp
Treatment - Drugs
Control group (40 patients) received 10 mg of medroxy progesterone from day 16 to 25 three-months. The patients were rechecked up after three and six months. Also Transvaginal sonography and endometri
Interventional group (40 patients) was treated by letrozole through a dosage of one tablet (2.5mg) per day over three months. The patients were rechecked up after three and six months. Also Transvagin

Sponsors

Vice chancellor of research, Bushehr University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: women of reproductive age; non-pregnant; the diagnosis of endometrial hyperplasia as ultrasound and pathology. Exclusion criteria: side effects of letrozole; the prohibition of medicine prescription.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
The effect of letrozole on endometrial thickness. Timepoint: Three months and six months. Method of measurement: Transvaginal sonography.

Secondary

MeasureTime frame
Reduction of irregular bleeding. Timepoint: Three months and six months. Method of measurement: History of the patients.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Elham Rahmani

Bushehr University of Medical Sciences

rahmani@bpums.ac.ir+98 77333455374

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026