coronary artery bypass graft. Atherosclerotic heart disease
Conditions
Interventions
Intervention 1: After weaning from cardiopulmonary bypass and infusion of protamine, “fibrinogen” solution including 1 g of fibrinogen in 50 mL volume is flushed over the heart
Afterwards, sternum is
whether fibrinogen or placebo. Intervention 2: In the control (placebo) group, after weaning from bypass circuit and protamine infusion, 50 mL of distilled water is flushed over the heart, exactly the
whether fibrinogen or placebo.
Treatment - Drugs
Placebo
In the control (placebo) group, after weaning from bypass circuit and protamine infusion, 50 mL of distilled water is flushed over the heart, exactly the same method as fibrinogen.
Finally afterward
After weaning from cardiopulmonary bypass and infusion of protamine, “fibrinogen” solution including 1 g of fibrinogen in 50 mL volume is flushed over the heart
Afterwards, sternum is closed and wir
Sponsors
Vice chancellor for research, Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age between 40-75 years old; elective CABG with CPB; constant surgeon; informed written consent. The following conditions were considered as exclusion criteria: emergent or urgent surgery; age more than 75 years or less than 40 years old; diabetes mellitus (or any of its complications like diabetic ketoacidosis or non-ketonic hyperosmolar diabetic coma); any previous history of stroke or underlying cerebral vascular disease; history of deep vein thrombosis; history of underlying hematologic disorders; any carotid plaque creating significant stenosis (stenosis > 75%); underlying pulmonary disorders affecting the spirometry indices significantly (>50% decrease); acute renal failure; chronic kidney disease causing serum Cr>2mg/dL; hepatic failure causing liver function test failure (> 3 times than normal); off pump CABG; any unwanted complication in the operation period; re-starting CPB after weaning from bypass; pulmonary artery pressure >30 before operation; ejection fraction<30%; congestive heart failure.
Exclusion criteria
Exclusion criteria:
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Hematocrit level. Timepoint: Early 24 hours hematocrit in postoperative period. Method of measurement: Preoperative and postoperative hematocrit level. | — |
Primary
| Measure | Time frame |
|---|---|
| Postoperative bleeding. Timepoint: Early 24 hours in postoperative period. Method of measurement: Postoperative amount of blood loss in chest tube bottles. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Dabbagh
Anesthesiology Research Center
Outcome results
None listed