Rabies. animal bites
Conditions
Interventions
Intervention 1: In intervention group PCEC will be administered with 5 doses on days 0, 3, 7, 14, and 28, in animal bite subjects, who are classified in the second group (emergency vaccination) and th
Treatment - Drugs
In intervention group PCEC will be administered with 5 doses on days 0, 3, 7, 14, and 28, in animal bite subjects, who are classified in the second group (emergency vaccination) and third (routine vac
In control group Vero will be administered with 5 doses on days 0, 3, 7, 14, and 28, in animal bite subjects, who are classified in the second group (emergency vaccination) and third (routine vaccinat
Sponsors
Center of Disease Control (CDC), Ministry of Health, Tehran, Iran
Eligibility
Sex/Gender
All
Age
5 Years to 55 Years
Inclusion criteria
Inclusion criteria: inclusion criteria: age between 5 and 55 years; volunteer to participate in the study. exclusion criteria: have a history of previous animal bites; receiving immunization against rabies previously; have a significant acute or chronic infectious disease; receiving transfusion with blood or blood products within the past month; concomitantly receiving corticosteroids or immunosuppressive drug therapy; have axillary temperature 37.5°C before injection; being pregnant in females
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lymphadenopathy. Timepoint: 30 minutes after each injection. Method of measurement: By physician.;Bruising. Timepoint: 30 minutes after each injection. Method of measurement: By physician.;Ittching. Timepoint: 30 minutes after each injection. Method of measurement: By physician.;Abscesses. Timepoint: 30 minutes after each injection. Method of measurement: b.;Erythema. Timepoint: 30 minutes after each injection. Method of measurement: By physician.;Swelling. Timepoint: 30 minutes after each injection. Method of measurement: By physician. | — |
Secondary
| Measure | Time frame |
|---|---|
| Dizziness. Timepoint: 3 day after each injection. Method of measurement: evaluate by the patirnt.;Stomach ache. Timepoint: 3 day after each injection. Method of measurement: evaluate by the patirnt.;Nausea. Timepoint: 3 day after each injection. Method of measurement: evaluate by the patirnt.;Weakness. Timepoint: 3 day after each injection. Method of measurement: evaluate by the patirnt.;Muscle aches. Timepoint: 3 day after each injection. Method of measurement: evaluate by the patirnt.;Fever. Timepoint: 3 days after each injection. Method of measurement: evaluated daily by patients.;Vomiting. Timepoint: 3 day after each injection. Method of measurement: evaluate by the patirnt. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRoghieh Ramezankhani
Center of Disease Control (CDC), Ministry of Health, Tehran, Iran
Outcome results
None listed