Patients needing orthopedic surgery of the lower limbs below the knee. Injury, poisoning and certain other consequences of external causes
Conditions
Interventions
Intervention 1: Intervention 1: In the intervention group 20 mg of memantine were administrated one hour before surgery for the patient. Intervention 2: Intervention 2: In the control group placebo we
Treatment - Drugs
Intervention 1: In the intervention group 20 mg of memantine were administrated one hour before surgery for the patient.
Intervention 2: In the control group placebo were administrated (a capsule containing starch inside the shed) one hour before surgery for the patient.
Sponsors
Vice Chancellor for research of Zahedan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria including age range between 18 and 60 years, having indications for spinal anesthesia, having surgery of the lower limbs below the knee for bone plaque embedding. Exclusion criteria including any postoperative complication requires surgical intervention, lack of consent to participate in the study, having a history of substance abuse, history of chronic disease such as diabetes, high blood pressure and etc. taking medication, having a mental illness, having known hypersensitivity to the ketamine drug, having mental retardation and loss of consciousness, hemodynamic disorders, bleeding disorders and anemia
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity. Timepoint: 30 and 60 minutes, 2, 12 and 24 hours after surgery. Method of measurement: VAS (Visual Analogue Scale) ruler. | — |
Secondary
| Measure | Time frame |
|---|---|
| Consumption of Analgesic amount. Timepoint: 30 and 60 minutes, 2, 12 and 24 hours after surgery. Method of measurement: mg. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactKhalil Souloki
Zahedan University of Medical Sciences
Outcome results
None listed