Comparison of two medications in reducing blood pressure and bleeding in sinus surgery

Comparison of propofol and dexmedetomidine in reducing blood pressure and bleeding during endoscopic sinus surgery

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015101814056N5

Enrollment

100

Registered

2016-01-09

Start date

2014-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic sinusitis. Chronic sinusitis

Interventions

Intervention 1: Dexmedetomidine, 1 µg/kg as initial dose and 0.4 to 0.8 µg/kg/h IV infusion. Propofol, 50-150 µg/kg/min IV infusion. Intervention 2: Propofol, 50-150 µg/kg/min IV infusion.

Prevention

Dexmedetomidine, 1 µg/kg as initial dose and 0.4 to 0.8 µg/kg/h IV infusion. Propofol, 50-150 µg/kg/min IV infusion.

Propofol, 50-150 µg/kg/min IV infusion.

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ASA class I–II; Age between 18-60 years old; Patients satisfaction; Not pregnant; No history of cardiovascular diseases (Arrhythmia, ischemia, and heart block); Not history of coagulopathies; Not taking opioids. Exclusion criteria: Sensitivity to the drugs used in this study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Mean arterial pressure. Timepoint: Every 15 minutes to the end of surgery. Method of measurement: Sphygmometer.;Bleeding volume. Timepoint: During surgery. Method of measurement: The number of gas consumed and the amount of blood suctioned.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Hesameddin Modir

Arak University of Medical Sciences

He_modir@yahoo.com+98 86 3417 3641

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026