Chronic renal failure. Chronic renal failure
Conditions
Interventions
Intervention 1: In the experimental group allopurinol 100 mg will be given under the supervision of nephrologist ,daily for 12 months. Then at beginning of the study, and at 3,6 and 12 months the kidn
Treatment - Drugs
Placebo
In the experimental group allopurinol 100 mg will be given under the supervision of nephrologist ,daily for 12 months. Then at beginning of the study, and at 3,6 and 12 months the kidney function of p
In the control group will receive 100 mg of placebo daily for 12 months. Then at beginning of the study, and at 3,6 and 12 months the kidney function of patients with GFR, uric acid and creatinine is
Sponsors
Vice chancellor for research, Kermanshah University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: informed consent of the patient;the diagnosis of renal glomerular filtration ;(GFR) of less than 60 and over 15; uric acid greater than 6 mg per dL; age over 18 years; no history of hospitalization during the past three months due to renal disease and no increase in creatinine number greater than 50% compared to the 3months ago. Exclusion criteria: allopurinol intolerance;allergy; the possibility of pregnancy; liver disease history of gout
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GFR level. Timepoint: At beginning of the study, and at 3,6 and 12 months after study. Method of measurement: Using the formula Modification of Diet in Renal Disease(MDRD).;Using the formula creatinine. Timepoint: At beginning of the study, and at 3,6 and 12 months after study. Method of measurement: Based on blood tests.;Uric acid. Timepoint: At beginning of the study, and at 3,6 and 12 months after study. Method of measurement: Based on blood tests. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed