Primary knee osteoarthrosis,. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group: corticosteroid with oxygen injection will be performed under the ultrasound guid in the knee joint which will be done by an experienced physical medicine and rehabi
using supra patellar approach. Intervention 2: Control group: corticosteroid with ozone injection will be performed under the ultrasound guid in the knee joint which will be done by an experienced phy
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Knee osteoarthritis based on the American College of Rheumatology criteria in grade 2 and 3, consistent with the Lawrence–Kellgren criteria. 2. Knee pain for at least six months. 3. Age between 18 and 75 years. 4. Absence of any acute or chronic infection. 5. Not pregnant and not planning pregnancy. 6. No intra-articular knee injection within the past three months. 7. Absence of inflammatory joint diseases or secondary osteoarthritis. 8. No history of knee surgery. 9. No severe underlying diseases such as uncontrolled diabetes, anticoagulant use, etc. 10. No daily use of opioid or non-opioid analgesics.
Exclusion criteria
Exclusion criteria: 1. Patients with major depression or other psychiatric disorders (such as needle phobia, etc.). 2. History of tumor or local infection in the knee area. 3. History of malignancies (multiple myeloma, bone metastases, leukemia, or lymphoma).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The severity of pain. Timepoint: Zero, one month, two and six months after. Method of measurement: Visual Analog Scale(VAS).;The severity of symptoms and functional limitations. Timepoint: Zero, one month, two and six months after. Method of measurement: By using WOMAC questionnare. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: one day,two and four weeks after. Method of measurement: Physical examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad hossein Taherian
Iran University of Medical Sciences
Outcome results
None listed