Primary knee osteoarthrosis, bilateral. Primary knee osteoarthrosis, bilateral
Conditions
Interventions
Intervention 1: Intervention group: mesenchimal stem cell injection will be performed under the ultrasound guid in the knee joint which will be done by an experienced physical medicine and rehabilitat
using supra patellar approach. Intervention 2: Control group: corticosteroid injection will be performed under the ultrasound guid in the knee joint which will be done by an experienced physical medic
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients with mild to moderate OA of the knee (Kellgren Lawrence grade I, II and III) Knee pain for at least six months Age 18 to 75 years old The absence of any acute or chronic infection No pregnancy or lack of planning to get pregnant No history of any intra articular knee injection in three months ago The absence of inflammatory articular disease or secondary osteoarthritis No history of knee surgery No severe underlying disease such as uncontrolled diabetes,Use of anticoagulants Lack of daily use of opioid and non opioid analgesics
Exclusion criteria
Exclusion criteria: The willingness of patients to exit from the study at any stage of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The severity of pain. Timepoint: Zero, two weeks, one and six months after. Method of measurement: Visual Analog Scale(VAS).;The severity of symptoms and functional limitations. Timepoint: Zero, two weeks, one and six months after. Method of measurement: By using WOMAC questionnare.;Range of motion. Timepoint: Zero, two weeks, one and six months after. Method of measurement: Goniometer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: two and four weeks after. Method of measurement: Physical examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactKhatereh Abdolmaleki
Iran University of Medical Sciences
Outcome results
None listed