Comparing local injection of ozone, corticosteroid and prolotherapy under ultrasound guidance in the treatment of inflammation of shoulder tendons

Comparing ultrasound guided injection of oxygen-ozone vs. corticosteroid vs. prolotherapy in the treatment of shoulder tendinopathy : a randomized, prospective, multicenter randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20151017024572N17

Enrollment

Registered

2018-07-12

Start date

2019-05-10

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation of the shoulder tendons. Mononeuropathy in diseases classified elsewhere

Interventions

Intervention 1: Intervention group (ozone therapy): 5cc ozone 20µg / L, in subacromial space with lateral aperture under ultrasound guidance. Intervention 2: Intervention group (porlotherapy): 5cc dex

Eligibility

Sex/Gender

All

Age

20 Years to 80 Years

Inclusion criteria

Inclusion criteria: The presence of tandinopathy in patients as a positive one in a special shoulder test, including: Neer test, Hawkins test Visual Analog Scale (VAS) above 4 Patient's desire to attend research project

Exclusion criteria

Exclusion criteria: Existence of a history and examination of rotator cuff tears, diabetes, coagulation disorders, fractures, rheumatologic diseases, tumors and infection Receiving injection in the shoulder joint in the last 3 months Frozen Shoulder Presence of c6-c5 synchronous radiculopathy

Design outcomes

Primary

Measure	Time frame
Pain score based on Visual Analogue Scale. Timepoint: Before injection, two weeks , two months and six months after the injection. Method of measurement: Visual Analog Scale (VAS).;Shoulder pain and disability. Timepoint: Before injection, two weeks , two months and six months after the injection. Method of measurement: Shoulder pain and disability index (SPADI).	—

Secondary

Measure	Time frame
Clinical Global Impression. Timepoint: Before injection, two weeks , two months and six months after the injection. Method of measurement: Clinical Global Impression Questionnaire.;Patient Global Impression of Improvement. Timepoint: Before injection, two weeks , two months and six months after the injection. Method of measurement: Patient Global Impression of Improvement Questionnaire.;Shoulder rang of motiom. Timepoint: Before injection, two weeks , two months and six months after the injection. Method of measurement: goniometer.;Subacromial bursaThickness. Timepoint: Before injection, two weeks , two months and six months after the injection. Method of measurement: sonography.;Constant Score. Timepoint: Before injection, two weeks , two months and six months after the injection. Method of measurement: Constant Score Questionnaire.	—

Measure

Time frame

Clinical Global Impression. Timepoint: Before injection, two weeks , two months and six months after the injection. Method of measurement: Clinical Global Impression Questionnaire.;Patient Global Impression of Improvement. Timepoint: Before injection, two weeks , two months and six months after the injection. Method of measurement: Patient Global Impression of Improvement Questionnaire.;Shoulder rang of motiom. Timepoint: Before injection, two weeks , two months and six months after the injection. Method of measurement: goniometer.;Subacromial bursaThickness. Timepoint: Before injection, two weeks , two months and six months after the injection. Method of measurement: sonography.;Constant Score. Timepoint: Before injection, two weeks , two months and six months after the injection. Method of measurement: Constant Score Questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactArash Babaie

Iran University of Medical Sciences

arashbabaie@gmail.com+98 21 86701

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026