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Evaluation of comparison between Remifentanil infusion and single dose intravenous Hydralazine + Propranolol administration to provide controlled hypotension in patients undergoing Rhino plastic surgery in khalili hospital during 2014-2015

Evaluation of comparison between Remifentanil infusion and single dose intravenous Hydralazine + Propranolol administration to provide controlled hypotension in patients undergoing Rhino plastic surgery in khalili hospital during 2014-2015

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2015101522173N2
Enrollment
80
Registered
2015-12-09
Start date
2015-09-23
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension. Hypertensive diseases

Interventions

Intervention 1: In group B patients are tested under Remifentanil infusion at a rate of 0.1 -0.3 mcg / kg / min . Intervention 2: Group A, besides induction of anesthesia , received 1mg Inderal and 20
Treatment - Drugs
In group B patients are tested under Remifentanil infusion at a rate of 0.1 -0.3 mcg / kg / min .
Group A, besides induction of anesthesia , received 1mg Inderal and 20mg Hydralazine.

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criterion: all patients in the range of 20-40 years old with class I ASA. Exclusion criteria: patients in class II & III ASA; recent (the last 3 months) general anesthesia record; drug abuse; history of allergy to Propranolol or Hydralazine or Remifentanil; high blood pressure; cardiovascular diseases should be eliminated.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Blood pressure. Timepoint: Before intervention, during intervention, after intervention. Method of measurement: In terms of mmHg, using a Mercury sphygmomanometer.

Secondary

MeasureTime frame
Bleeding during surgery. Timepoint: After intervention. Method of measurement: According to surgeon report.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Seyyed Ebrahim Sadeghi

Shiraz University of Medical Sciences

esadeghi@sums.ac.ir+98 71 3227 4250

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026