Ovarian rejuvenation in diminished ovarian reserve patients. Female infertility
Conditions
Interventions
Intervention 1: intervention group: Hormonal and ovarian reserve tests including LH, FSH, AMH, progesterone, estradiol are requested on the third day of the menstrual cycle. In the first group, on the
Sponsors
Yazd University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 20-40 years old POSEIDON criteria for groups 3 and 4 (antral follicle count less than 5 and AMH less than 1.2 ng/ml): Candidates for IVF/ICSI At least one canceled IVF cycle due to lack of response, or two or more previous oocyte retrieval failures in previous IVF cycles within the past year (number of oocytes retrieved less than or equal to 3) The presence of at least one ovary with a volume more than 1 ml Infertility for more than one year Serum FSH more than or equal to 10 and less than or equal to 20
Exclusion criteria
Exclusion criteria: History of hematologic, autoimmune, coagulation, endocrine, renal, cardiac, malignant diseases, or allergies Uterine anomalies, hydrosalpinx, ovarian/uterine masses (fibroids, polyps), adenomyosis Severe male infertility (azoospermia and severe oligospermia) Addiction to drugs, alcohol, or use of psychotropic substances Coagulation disorders and treatment with anticoagulant drugs Body mass index (BMI) below 18 kg/m² or above 30 kg/m² Anemia (hemoglobin <10 g/dL), thrombocytopenia (platelets <105,000/µL), and neutropenia (neutrophils <1500/µL) Previous history of lower abdominal surgery Use of G-CSF within the past three months, hormonal therapy one month before and after PRP Lack of patient follow-up Clinical hyperandrogenism Recent infectious disease (any febrile illness of infectious origin, e.g., recent lung infection) Severe endometriosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy. Timepoint: 2 and 6 weeks after embryo transfer, 12 weeks of pregnancy. Method of measurement: Laboratory test(beta hcg titre), ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| Chemical pregnancy. Timepoint: 2 weeks after embryo transfer. Method of measurement: Pregnancy laboratory test (beta hcg titre).;Clinical pregnancy. Timepoint: 6 weeks after embryo transfer. Method of measurement: vaginal ultrasound.;Ongoing pregnancy. Timepoint: 10 weeks after embryo transfer. Method of measurement: vaginal ultrasound. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahrzad moeinaddini
Yazd University of Medical Sciences
Outcome results
None listed