Assessing the effectiveness of Aloe vera 2% gel in treatment of Cutaneous Leishmaniasis (CL) on the base of Traditional Persian Medicine (TPM)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015101224490N1

Enrollment

Registered

2016-05-03

Start date

2015-11-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cutaneous leishmaniasis. Cutaneous leishmaniasis

Interventions

Intervention 1: Intervention group: Aloe vera 2% Gel two times a day a layer until the full lesion epithelialization or up to 4 weeks after last intervention. Intervention 2: Control group: P

Treatment - Drugs

Placebo

Intervention group: Aloe vera 2% Gel two times a day a layer until the full lesion epithelialization or up to 4 weeks after last intervention

Control group: Placebo Gel two times a day a layer until the full lesion epithelialization or up to 4 weeks after last intervention

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with lesions which lasts more than 14 days and definitely diagnosed cutaneous leishmaniasis by parasites seen in smears taken from skin lesions, and treating by the national standard treatment guidelines, after complete description of the study, in the case of consent to participate in the study are? Exclusion criteria: pregnant women, patients with allergy to antimuan, patients taking more than three months have passed since the first appearance of skin lesions, patients in recent months any way be used to treat leishmaniasis, patients which their wound on the eyelids, ear, nose or are less than one centimeter is near the end of the lips and eyes

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Longest diameter of ulceration area. Timepoint: 0,7,14,21,28 day& if not cured 4 week after last intervention. Method of measurement: ruler.;Longest diameter of Induration area. Timepoint: 0,7,14,21,28 day& if not cured 4 week after last intervention. Method of measurement: ruler.;Healing rate. Timepoint: 0,7,14,21,28 day& if not cured 4 week after last intervention. Method of measurement: observation & calculation.;Treatment resualt. Timepoint: at the end of treatmen, and if lesion not full epithelialized 4 weeks after last intervention. Method of measurement: observation & determination.	—

Measure

Time frame

Longest diameter of ulceration area. Timepoint: 0,7,14,21,28 day& if not cured 4 week after last intervention. Method of measurement: ruler.;Longest diameter of Induration area. Timepoint: 0,7,14,21,28 day& if not cured 4 week after last intervention. Method of measurement: ruler.;Healing rate. Timepoint: 0,7,14,21,28 day& if not cured 4 week after last intervention. Method of measurement: observation & calculation.;Treatment resualt. Timepoint: at the end of treatmen, and if lesion not full epithelialized 4 weeks after last intervention. Method of measurement: observation & determination.

—

Secondary

Measure	Time frame
Side effect. Timepoint: during treatment. Method of measurement: observation & interview.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactOmid Mozafari

Mazandaran University of Medical Sciences

dr.mozafari@goums.ac.ir+98 11 3324 4893

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026