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Comparison of clonidine and tranexamic acid on the control of lumbar surgical bleeding

Comparison of the effect of oral clonidine and intravenous Tranexamic acid on bleeding control in posterior lumbar spine fusion surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20151012024493N5
Enrollment
136
Registered
2023-02-17
Start date
2023-03-06
Completion date
Unknown
Last updated
2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bleeding. Intraoperative hemorrhage and hematoma of a nervous system organ or structure complicating other procedure

Interventions

Intervention 1: Intervention group 1: 30 minutes before surgery, this group will be given an oral clonidine tablet of 0.2 mg to drink with 50 ml of water. This pill will be given to the patient only o
The drug used will be purchased from Abidi Pharmaceuticals. Intervention 2: Intervention group 2: This group will be given the drug tranexamic acid 10 mg per kilogram and after the start of the surger

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: American Society of Anesthesiology (ASA) physical class I and II Candidate for posterior lumbar spine fusion surgery Patient satisfaction Age 18-50 years

Exclusion criteria

Exclusion criteria: Hemoglobin less than 10 Having hemophilia

Design outcomes

Primary

MeasureTime frame
Bleeding. Timepoint: Record the amount of bleeding at the beginning of the surgery, at the end of the surgery and then every six hours for three days after the surgery. Method of measurement: Observing the amount of blood in surgical suction, gas and surgical lunggas, and blood observed in the surgical drain.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParisa Sezari

Shahid Beheshti University of Medical Sciences

parissasezari@yahoo.com+98 21 5542 4040

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026