laminectomy for lumbar disc herniation. Other intervertebral disc displacement, lumbar region
Conditions
Interventions
Intervention 1: Intervention group: In this group intravenous infusion of dexmedetomidine will be added to routine anesthetic drugs during the surgury. Intervention 2: Control group: Anesthesia is mai
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 18-65 years old patients Candidate for elective one-level lumbar laminectomy surgery No previous history of any diseases (ASA class 1) No previous history of spinal surgery Patients with BMI less than 30 kg/m2 Filling the informed consent form No history of addiction to opioids, psychedelics or alcohol No previous history of long-term consumption of corticosteroids, NSAIDs or COX inhibitors No history of consumption of antioxidants such as vitamin E or C or any herbal medications
Exclusion criteria
Exclusion criteria: Bleeding more than 10% of total blood volume Duration of surgery longer than 4 hours Changes in surgical plan( including: laminectomy more than one level, diskectomy, posterior spinal fusion) Requiring transfusion of blood products Required to be treated by inotropes or vasopressors
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Glutathione peroxidase level. Timepoint: Before anesthesia induction in operating room and at the end of the surgery in post anesthetic care unit. Method of measurement: Glutathione peroxidase activity assay kit.;Serum Superoxide dismutase level. Timepoint: Before anesthesia induction in operating room and at the end of the surgery in post anesthetic care unit. Method of measurement: Superoxide dismutase activity assay kit.;Serum catalase level. Timepoint: Before anesthesia induction in operating room and at the end of the surgery in post anesthetic care unit. Method of measurement: Catalase activity assay kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParisa Sezari
Shahid Beheshti University of Medical Sciences
Outcome results
None listed