Inflammatory response during craniotomy based administered on anesthetic drugs. Neoplasm of uncertain behavior of brain, supratentorial
Conditions
Interventions
Intervention 1: Intervention group: In the propofol group, 100-300 microgram per kilogram of bodyweight per minutes of intravenous propofol is used as the anesthetic of choice for anesthesia maintenan
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ASA Class= 1,2 Candidate for craniotomy due to supratentorial tumors 18-65 years old
Exclusion criteria
Exclusion criteria: History of Rheumatologic diseases Consuming anti inflammatory medications Allergy to the medications prescribed during the study History of taking beta blocker or calcium channel blocker medications, or vitamin supplements Probable need of transfusing more than 4 units of packed red blood cell during the surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Glutathione peroxidase level. Timepoint: Before anesthesia induction in operating room and at the end of the surgery in post anesthetic care unit. Method of measurement: Glutathione peroxidase activity assay kit.;Serum Superoxide dismutase level. Timepoint: Before anesthesia induction in operating room and at the end of the surgery in post anesthetic care unit. Method of measurement: Superoxide dismutase activity assay kit.;Serum catalase level. Timepoint: Before anesthesia induction in operating room and at the end of the surgery in post anesthetic care unit. Method of measurement: Catalase activity assay kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParisa Sezari
Shahid Beheshti University of Medical Sciences
Outcome results
None listed