The effect of cumin extract on type 2 diabetes

The effect of Cuminum Cyminum extract on glycemic indexes, serum hsCRP, TNF-a, lipid profile and anthropometric indexes in type II diabetic patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015101113678N9

Enrollment

100

Registered

2016-03-16

Start date

2015-10-07

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes. Non-insulin-dependent diabetes mellitus

Interventions

Intervention 1: Intervention group 1: Cuminum Cyminum extract (Barij Essence company) , soft gel 25 milligrams , four times daily for 8 weeks. Intervention 2: Intervention group 2: Cuminum Cyminum ext

Treatment - Drugs

Placebo

Intervention group 1: Cuminum Cyminum extract (Barij Essence company) , soft gel 25 milligrams , four times daily for 8 weeks

Intervention group 2: Cuminum Cyminum extract(Barij Essence company) , soft gel 25 milligrams , twice daily for 8 weeks

Intervention group 3: placebo (oral paraffin oil) , soft gel 25 milligrams(Zahravi company) , twice daily for 8 weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria FBS higher than 126 mg/dL and lower than 200 mg/dL; controlled statues of lipid and sugar of the blood; single medication schedule in the samples; lack of insulin therapy; do not to use of tobacco and alcohol; absence of the chronic disease; lack of pregnancy and lactation; lack of menopause; and lack of hormone therapy. Exclusion criteria: Sensitivity to the extract of the green cumin; conception during study; variation in the dose of the medications during study; and developing to the diseases during study

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Body Mass Index. Timepoint: Before and after 8 weeks intervention. Method of measurement: Formula.;Body fat percent. Timepoint: Before and after 8 weeks intervention. Method of measurement: Caliper.;Non fat tissue percentage. Timepoint: Before and after 8 weeks intervention. Method of measurement: Caliper.;Waist circumference. Timepoint: Before and after 8 weeks intervention. Method of measurement: Meter.;High sensitive C Reactive Protein. Timepoint: Before and after 8 weeks intervention. Method of measurement: ELISA.;Total Cholesterol. Timepoint: Before and after 8 weeks intervention. Method of measurement: Enzymatic.;Low Density Lipoprotein. Timepoint: Before and after 8 weeks intervention. Method of measurement: Enzymatic.;High Density Lipoprotein. Timepoint: Before and 8 weeks after intervention. Method of measurement: Enzymatic.;Very Low Density Lipoprotein. Timepoint: Before and after 8 weeks intervention. Method of measurement: Enzymatic.;Fast Blood Sugar. Timepoint: Before and after 8 weeks intervention. Method of measurement: Enzymatic.;Insulin. Timepoint: Before and after 8 weeks intervention. Method of measurement: ELISA.;Hemoglobin A1c. Timepoint: Before and after 8 weeks intervention. Method of measurement: Colorimetry.;Insulin resistance. Timepoint: Before and after 8 weeks intervention. Method of measurement: Formula.;Tumor Necrosis Factor. Timepoint: Before and after 8 weeks intervention. Method of measurement: ELISA.	—

Measure

Time frame

Body Mass Index. Timepoint: Before and after 8 weeks intervention. Method of measurement: Formula.;Body fat percent. Timepoint: Before and after 8 weeks intervention. Method of measurement: Caliper.;Non fat tissue percentage. Timepoint: Before and after 8 weeks intervention. Method of measurement: Caliper.;Waist circumference. Timepoint: Before and after 8 weeks intervention. Method of measurement: Meter.;High sensitive C Reactive Protein. Timepoint: Before and after 8 weeks intervention. Method of measurement: ELISA.;Total Cholesterol. Timepoint: Before and after 8 weeks intervention. Method of measurement: Enzymatic.;Low Density Lipoprotein. Timepoint: Before and after 8 weeks intervention. Method of measurement: Enzymatic.;High Density Lipoprotein. Timepoint: Before and 8 weeks after intervention. Method of measurement: Enzymatic.;Very Low Density Lipoprotein. Timepoint: Before and after 8 weeks intervention. Method of measurement: Enzymatic.;Fast Blood Sugar. Timepoint: Before and after 8 weeks intervention. Method of measurement: Enzymatic.;Insulin. Timepoint: Before and after 8 weeks intervention. Method of measurement: ELISA.;Hemoglobin A1c. Timepoint: Before and after 8 weeks intervention. Method of measurement: Colorimetry.;Insulin resistance. Timepoint: Before and after 8 weeks intervention. Method of measurement: Formula.;Tumor Necrosis Factor. Timepoint: Before and after 8 weeks intervention. Method of measurement: ELISA.

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Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026