Physical Activity and Migraine

Survy on 8 weeks of endurance training effectiveness with different intensities on plasma level of the content of Calcitonin Gene-Related Peptide (CGRP) and Nitric Oxide (NO) in Patients with Migraine Disorder

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015100910824N2

Enrollment

Registered

2015-12-05

Start date

2015-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Maigraine. Use additional external cause code (Chapter XX), if desired, to identify drug, if drug-induced.

Interventions

Intervention 1: Intervention 1: Moderate Intensity Aerobic training will be performed with 13-15 Borg RPE Scale for 40 minute per session. Intervention 2: Intervention 2: High Intensity Aerobic traini

Intervention 1: Moderate Intensity Aerobic training will be performed with 13-15 Borg RPE Scale for 40 minute per session.

Intervention 2: High Intensity Aerobic training will be performed with 15-17 Borg RPE Scale for 30 minute per session.

Control Group: There is no any intervention in this group.

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: inclusion criteria: The age of patients should be on rage of 18 to 45 years; the patients have not been involving in regular exercise activity experience since 6 months ago; they do not have experience in chronic disease such as cardiovascular disease, hypertension, diabetes, arthritis, cancer, asthma, HIV, meningitis and Multiple Sclerosis; The migraine headache (aura and without aura) must be confirmed by neurologist; and inclusion criteria in the VO2max testing is 20 ml/min/kg. Exclusion criteria: The patient do extra exercise training; the patient be absent more than 3 session continuously during exercise training; and the patient voluntary give up the training program during or any of the stages of research.

Exclusion criteria

Exclusion criteria:

Design outcomes

Secondary

Measure	Time frame
Migraine Index (intensity-frequency-duration). Timepoint: One month before and one mount after of the intervention. Method of measurement: Migraine Index questionnaire.	—

Primary

Measure	Time frame
CGRP, NO. Timepoint: Blood sampling 48 hours before and after innervation. Method of measurement: Using CGRP and NO ELISA Kits.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Pairo

Razi University

zahrapairo@gmail.com+98 83 3427 4585

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026