Comparison of the effects of High flow nasal cannula versus nasal continuous positive Air way pressure in treatment of respiratory distress syndrome in premature newborns

A comparative study of effectiveness and ineffectiveness of the nasal cannula with high pressure and continuous positive airway pressure through the nose for the treatment of premature infants with respiratory distress syndrome

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015100814333N41

Enrollment

200

Registered

2015-10-19

Start date

2015-07-06

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory distress syndrome. Respiratory distress syndrome of newborn

Interventions

Intervention 1: In the first group after the injection of the surfactant and Extube, Placed under respiratory support with nasal (CPAP) and initiation of treatment is with 4 ml of water and Fio2 40%.

Treatment - Drugs

In the first group after the injection of the surfactant and Extube, Placed under respiratory support with nasal (CPAP) and initiation of treatment is with 4 ml of water and Fio2 40%. Then the duratio

In the second group respiratory support is established using the oxygen hot and humid high flow through nasal cannula (HFNC). Blender and nasal cannula devices with an inner diameter of 2 mm is use

Eligibility

Sex/Gender

All

Age

6 Months to 9 Months

Inclusion criteria

Inclusion criteria: Inclusion criteria: premature infants under 37 weeks and over 24 weeks; respiratory distress syndrome; written informed consent of the parents Exclusion criteria: Apgar score of fifth minute less than 5; there are syndromes or major congenital anomalies; congenital heart disease, mother Radiography and chorioamnionitis

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Cerebral hemorrhage. Timepoint: During study. Method of measurement: By cerebral ultrasound.;Necrotizing enterocolitis. Timepoint: During study. Method of measurement: Based on the clinical symptoms and a doctor observation and an abdominal radiograph.;Amount of nasal septum injury. Timepoint: During study. Method of measurement: Based on the doctor examination.;Air leak syndrome. Timepoint: During study. Method of measurement: Based on the clinical symptoms and doctor observation and chest radiography.;Broncho-pulmonary dysplasia. Timepoint: During study. Method of measurement: Based on the clinical symptoms, doctor observation, x-ray and laboratory.;The need for re-intubating. Timepoint: During study. Method of measurement: Based on laboratory and doctor clinical examination.	—

Measure

Time frame

Cerebral hemorrhage. Timepoint: During study. Method of measurement: By cerebral ultrasound.;Necrotizing enterocolitis. Timepoint: During study. Method of measurement: Based on the clinical symptoms and a doctor observation and an abdominal radiograph.;Amount of nasal septum injury. Timepoint: During study. Method of measurement: Based on the doctor examination.;Air leak syndrome. Timepoint: During study. Method of measurement: Based on the clinical symptoms and doctor observation and chest radiography.;Broncho-pulmonary dysplasia. Timepoint: During study. Method of measurement: Based on the clinical symptoms, doctor observation, x-ray and laboratory.;The need for re-intubating. Timepoint: During study. Method of measurement: Based on laboratory and doctor clinical examination.

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Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026