The effect of autologous leukocyte platelet rich fibrin (LPRF) on the rate of orthodontic tooth movement- a prospective randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015100724405N1

Enrollment

Registered

2016-03-23

Start date

2015-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

orthodontic tooth movement. Other specified medical care

Interventions

Intervention 1: in this study, after leveling in each quadrant of upper and lower arches, the extracted sockets would recieve LPRF in case group. Intervention 2: In control group, no LPRF would be app

in this study, after leveling in each quadrant of upper and lower arches, the extracted sockets would recieve LPRF in case group.

In control group, no LPRF would be applied in empty extracted sockets.

Eligibility

Sex/Gender

All

Age

12 Years to 25 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: more than12 years old patients; bilaterally symmetric extraction of premolar teeth; no medicines or systemic illness; full banding/bonding of teeth in both arches. Exclusion Criteria: pregnancy; non-extraction treatment; syndromic &systemic illness or medication like NSAIDS that interfere with OTM; prior orthodontic treatment.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The amount of tooth movementand to compare the amount of tooth movement between maxillary and mandibular arches. Timepoint: [Time Frame: 0 days, 15 days, 1st month, 1.5 and 2nd month, 2.5 and 3rd month after start of treatment and conventional orthodontic]. Method of measurement: The amounts of OTM will be measured by comparing the changes of distance between the adjacent teeth in two weeks interval for three months. The exact amounts of tooth movement will be measured clinically by Boley Gauge Caliper with sharp tips located at the CEJ of crowns of the casts and then will be compared and double checked by another independent blind examiner ( to evaluate the interobserver and intraobserver reliability).	—

Measure

Time frame

The amount of tooth movementand to compare the amount of tooth movement between maxillary and mandibular arches. Timepoint: [Time Frame: 0 days, 15 days, 1st month, 1.5 and 2nd month, 2.5 and 3rd month after start of treatment and conventional orthodontic]. Method of measurement: The amounts of OTM will be measured by comparing the changes of distance between the adjacent teeth in two weeks interval for three months. The exact amounts of tooth movement will be measured clinically by Boley Gauge Caliper with sharp tips located at the CEJ of crowns of the casts and then will be compared and double checked by another independent blind examiner ( to evaluate the interobserver and intraobserver reliability).

—

Secondary

Measure	Time frame
Mucogingival defects, gingival recession, clinical attachement loss, probing depth, width of keratinized gingiva. Timepoint: Time Frame: 0 days, 15 Days, 1st month, 1.5 month. Method of measurement: aesculap periodontal probe.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Azita Tehranchi

Dental Research Center, Research Institute of Dental Sciences

azitatehranchi@yahoo.com+98 21 2242 7752

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026