Evaluation of heliox efficacy in acute asthma attack

Evaluation of the effect of clinical and peak expiratory flow rate of nebulization of Albuterol and Heliox (helium 70%,oxygen 20%) versus nebulization of Albuterol and Oxygen during acute asthma exacerbation

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015100715446N6

Enrollment

Registered

2015-11-06

Start date

2015-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute attack asthma. Asthma

Interventions

Intervention 1: Intervention Group: Salbutamol 2.5mg each 20 minutes via nebulizer Atrovent 2.5mg each 20 minutes 3 times during 60 minutes via oral Prednisolone 50mg one time.Heliox accompanying Albu

Treatment - Drugs

Intervention Group: Salbutamol 2.5mg each 20 minutes via nebulizer Atrovent 2.5mg each 20 minutes 3 times during 60 minutes via oral Prednisolone 50mg one time.Heliox accompanying Albuterol 10 mil/lit

Control Group: Salbutamol 2.5mg each 20 minutes with nebulizer Atrovent 2.5mg each 20 minutes 3 times during 60 minutes with oral Prednisolone 50mg one time.Clinical State,FEV1,PEFR measure and record

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Acute Asthma Attack with minimum of 18 years old and maximum of 55year; Exclusion Criteria: History of Smoking more than 10 pack/ years; History of chronic bronchitis; acute medical problem; History of Cardiovascular Diseases;cardiac arythmia; Pregnant women; treatment with nebulization of beta agonist during 6 hours ago.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Clinical state. Timepoint: Before intervention 20,40,60 minutes after intervention. Method of measurement: Base on alert status,talking,wizing,use of respiratory muscles.;Forced Expiratory Volum in First Second (FEV1). Timepoint: Before intervention 20,40,60 minutes after intervention. Method of measurement: Mililiter with use of Peak Flow Meter.;Peak Expiratory Flow Rate(PEFR). Timepoint: Before intervention 20,40,60 minutes after intervention. Method of measurement: Mililiter with use of Peak Flow Meter.	—

Measure

Time frame

Clinical state. Timepoint: Before intervention 20,40,60 minutes after intervention. Method of measurement: Base on alert status,talking,wizing,use of respiratory muscles.;Forced Expiratory Volum in First Second (FEV1). Timepoint: Before intervention 20,40,60 minutes after intervention. Method of measurement: Mililiter with use of Peak Flow Meter.;Peak Expiratory Flow Rate(PEFR). Timepoint: Before intervention 20,40,60 minutes after intervention. Method of measurement: Mililiter with use of Peak Flow Meter.

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Secondary

Measure	Time frame
Blood pressure. Timepoint: Before intervention 20,40,60 minutes after intervention. Method of measurement: mm Hg.;Pulse Rate. Timepoint: Before intervention 20,40,60 minutes after intervention. Method of measurement: Rate/Minutes.;Respiratory Rate. Timepoint: Before intervention 20,40,60 minutes after intervention. Method of measurement: Rate/Minutes.;Saturation of arterial blood oxygen (SO2 %). Timepoint: Before intervention 20,40,60 minutes after intervention. Method of measurement: with Pulse Oximetry.;Pulsus Paradox. Timepoint: Before intervention 20,40,60 minutes after intervention. Method of measurement: 10 reduse of Blood Pressure during inspiration.	—

Measure

Time frame

Blood pressure. Timepoint: Before intervention 20,40,60 minutes after intervention. Method of measurement: mm Hg.;Pulse Rate. Timepoint: Before intervention 20,40,60 minutes after intervention. Method of measurement: Rate/Minutes.;Respiratory Rate. Timepoint: Before intervention 20,40,60 minutes after intervention. Method of measurement: Rate/Minutes.;Saturation of arterial blood oxygen (SO2 %). Timepoint: Before intervention 20,40,60 minutes after intervention. Method of measurement: with Pulse Oximetry.;Pulsus Paradox. Timepoint: Before intervention 20,40,60 minutes after intervention. Method of measurement: 10 reduse of Blood Pressure during inspiration.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Hasan Motamed

Ahvaz Golestan Hospital

Hasan_motamed@yahoo.com+98 61 3374 3079

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026