multiple sclerosis. Demyelinating disease of the central nervous system
Conditions
Interventions
Endurance training intervention for HR - controlled at 50 - 60 rpm is in a lactate threshold. (Equivalent to 70% HR peak or 60% vo2 peak) on a 6-week cycle is carried out and CPET testing and EKG w
Rehabilitation
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: definite diagnosis of MS; the MS patients must have passed at least one year of their diagnosis; patients beable to move and walk; age 18-50 years old; all subjects should be sedentary (less than 2 hours of physical activity during a week); they do not have to orthopedic and any chronic illness that not being able to exercise or have an effect on the cardio-pulmonary system; none of the samples should not take medicines that affect on HR. Exclusion criteria: dementia; alcohol consumption; pregnancy; relapsing MS in a month to study; pacemaker or any disruptions or other serious cardiovascular and respiratory and orthopedic that prevents people from exercising their maximum limit; beta-blockers consumption.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiorespiratory fitness and cardiovascular autonomic contro. Timepoint: Before and 6 weeks after intervention. Method of measurement: cardiopulmonary exercise test. | — |
Secondary
| Measure | Time frame |
|---|---|
| The effect of aerobic exercise on fatigue variables. Timepoint: Before and 6 weeks after intervention. Method of measurement: Fatigue questionnaire.;Effects of aerobic training on EDSS variables. Timepoint: Before and 6 weeks after intervention. Method of measurement: Krutze criteria.;The effect of aerobic exercise on respiratory function such as: Vo2/HR, O2 pulse, PETCO2, PETO2, Vd/vt, vt, RR, VE, Vco2 peak RER, VE/VCO2. Timepoint: Before and 6 weeks after intervention. Method of measurement: Cardiopulmonary exercise tes.;The effect of aerobic exercise on walking capacity variables. Timepoint: Before and 6 weeks after intervention. Method of measurement: Questionnaire about physical activity (IPAQ. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Reza Aali
Tehran University of Medical Sciences
Outcome results
None listed