Infertility. Complication associated with artificial fertilization, unspecified
Conditions
Interventions
Intervention 1: In intervention group 0/25 mg/vial cetrorelix( GNRH antagonist), one vial daily, subcutaneous, for 7 days, before starting COH. Then start ovarian stimulation with 375 units of gonadot
Sponsors
Vice Chancellor for research of Shahid Sadoughi University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Poor ovarian responders according to Bologna criteria. At least two of the following three features must be present: Advanced maternal age (=40 years) or any other risk factor for poor ovarian response; A previous poor ovarian response (=3 oocytes with a conventional stimulation protocol); An abnormal ovarian reserve test (i.e. AFC <5–7 follicles or AMH <1.1 ng/ml). Two episodes of POR after maximal stimulation are sufficient to define a patient as poor responder.
Exclusion criteria
Exclusion criteria: History of endocrine and metabolic disorders endometriosis azoospermia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mature oocytes count. Timepoint: Oocyte retrieval day. Method of measurement: Counting number of mature oocytes with microscope.;Total oocytes count. Timepoint: Oocyte retrieval day. Method of measurement: Counting number of total oocytes with microscope. | — |
Secondary
| Measure | Time frame |
|---|---|
| Fertilization rate (two-pronuclear [2PN]/ MII). Timepoint: 16 hr after Intra-cytoplasmic sperm injection. Method of measurement: With microscope.;Implantation rate (the number of gestational sacs divided/the number of transferred embryos). Timepoint: 3 week after positive serum ßhCG. Method of measurement: Vaginal ultrasonography.;Ongoing pregnancy rate. Timepoint: after 12 week gestation. Method of measurement: ultrasound.;Miscarriage rate. Timepoint: miscarriages before 20 weeks gestation. Method of measurement: ultrasound.;Total dosage of gonadotropin. Timepoint: End of IVF cycle. Method of measurement: Count the dose of gonadotropin received.;Ovarian stimulation days. Timepoint: End of IVF cycle. Method of measurement: Counting the days of ovarian stimulation.;Number of embryo. Timepoint: On the 2nd day after ICSI. Method of measurement: Observation with microscope.;Chemical pregnancy. Timepoint: 14 days after embryo transfer. Method of measurement: Serum ßhCG.;Clinical pregnancy. Timepoint: 3 weeks after positive serum ßhCG. Method of measurement: Vaginal ultrasonography.;Oocyte maturity rate (MII number /total oocytes number). Timepoint: oocyte retrieval day. Method of measurement: with microscope.;Oocyte yield (total oocytes number /antral follicle count [AFC]). Timepoint: oocyte retrieval day for oocyte count and before the start of the ivf cycle for antral follicles. Method of measurement: With microscope for oocytes and vaginal ultrasound for antral follicles.;Mature oocyte yield (MII number/AFC). Timepoint: oocyte retrieval day for mature oocyte count and before the start of the ivf cycle for antral follicles. Method of measurement: With microscope for mature oocytes and vaginal ultrasound for antral follicles. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRobabe Hosseinisadat
Kerman University of Medical Sciences
Outcome results
None listed