Effect of exercise training on endothelial function of type 2 diabetes

Effect of differential exercise training on endothelial function of type 2 diabetes and relation with inflammatory cytokines

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2015100423002N2

Enrollment

Registered

2016-03-04

Start date

2015-03-20

Completion date

Unknown

Last updated

2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 2diabetes. Non-insulin-dependent diabetes mellitus

Interventions

Intervention 1: Intervention group 1: High- volume high- intensity interval training that consists of 6 intervals 4 minutes at 85- 90% HRmax which separated by 3 minutes at 45-50% HRmax. Intervention

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: History of type 2 diabetes more than 2 years No history of 6 months of regular exercise Glycosylated hemoglobin <6%(HbA1C <6%) Body mass index over 25 Hypertension uncontrolled pre or I stage

Exclusion criteria

Exclusion criteria: HbA1c over 10% Fasting blood glucose more than 400 mg/dl Functional limitations (such as osteoarthritis) Liver and kidney disease Myocardial infarction Coronary artery bypass surgery or angioplasty Chronic heart failure Cardiac arrhythmia's Smoking Uncontrolled BP (BP < 170/100 mmHg) Insulin therapy

Design outcomes

Primary

Measure	Time frame
Nitrite/Nitrate plasma. Timepoint: Before and after 12 week intervention. Method of measurement: ELISA kit.;Endothelin-1. Timepoint: Before and after 12 week intervention. Method of measurement: ELISA kit.;Flow mediated dilation. Timepoint: Before and after 12 week intervention. Method of measurement: Ultrasound doppler.;Carotid intima-media thickness. Timepoint: Before and after 12 week intervention. Method of measurement: Ultrasound doppler.;Insulin resistance. Timepoint: Before and after 12 week intervention. Method of measurement: HOMA-IR.;Glucose. Timepoint: Before and after 12 week intervention. Method of measurement: Enzymatic.;Applin. Timepoint: Before and after 12 week intervention. Method of measurement: ELISA kit.;Peak consumption oxygen. Timepoint: Before and after 12 week intervention. Method of measurement: Gas analyser system.;Diastolic and systolic blood pressure. Timepoint: Before and after 12 week intervention. Method of measurement: oscillometric device.;Heart rate rest. Timepoint: Before and after 12 week intervention. Method of measurement: Cornometer/ numbere.;Lipid profile. Timepoint: Before and after 12 week intervention. Method of measurement: Enzymatic.;Malondealdehid. Timepoint: Before and after 12 week intervention. Method of measurement: ELISA kit.;Glutathion proxidase. Timepoint: Before and after 12 week intervention. Method of measurement: ELISA kit.;Insulin. Timepoint: Before and after 12 week intervention. Method of measurement: ELISA kit.	—

Measure

Time frame

Nitrite/Nitrate plasma. Timepoint: Before and after 12 week intervention. Method of measurement: ELISA kit.;Endothelin-1. Timepoint: Before and after 12 week intervention. Method of measurement: ELISA kit.;Flow mediated dilation. Timepoint: Before and after 12 week intervention. Method of measurement: Ultrasound doppler.;Carotid intima-media thickness. Timepoint: Before and after 12 week intervention. Method of measurement: Ultrasound doppler.;Insulin resistance. Timepoint: Before and after 12 week intervention. Method of measurement: HOMA-IR.;Glucose. Timepoint: Before and after 12 week intervention. Method of measurement: Enzymatic.;Applin. Timepoint: Before and after 12 week intervention. Method of measurement: ELISA kit.;Peak consumption oxygen. Timepoint: Before and after 12 week intervention. Method of measurement: Gas analyser system.;Diastolic and systolic blood pressure. Timepoint: Before and after 12 week intervention. Method of measurement: oscillometric device.;Heart rate rest. Timepoint: Before and after 12 week intervention. Method of measurement: Cornometer/ numbere.;Lipid profile. Timepoint: Before and after 12 week intervention. Method of measurement: Enzymatic.;Malondealdehid. Timepoint: Before and after 12 week intervention. Method of measurement: ELISA kit.;Glutathion proxidase. Timepoint: Before and after 12 week intervention. Method of measurement: ELISA kit.;Insulin. Timepoint: Before and after 12 week intervention. Method of measurement: ELISA kit.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Ghardashi Afousi

University of Tehran

Ghardashi.a@ut.ac.ir+98 21 8201 5031

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026