Women with repeated implantation failure or Female infertile. Female infertility
Conditions
Interventions
Intervention 1: Intervention group: Oral hydroxychloroquine 200 mg twice daily (total 400 mg daily), starting on the second day of the menstrual cycle before the IVF cycle and continuing until 10 week
Sponsors
Kerman University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: History of =2 consecutive implantation failures (defined as failure to detect a gestational sac on ultrasound after transfer of =2 good-quality embryos in fresh or frozen cycles). Absence of structural uterine abnormalities (confirmed by hysteroscopy or son hysterography). Absence of contraindications to HCQ use (including retinopathy and G6PD deficiency). Normal parental karyotype (confirmed through previous testing)
Exclusion criteria
Exclusion criteria: Known thrombophilia, antiphospholipid syndrome, or autoimmune disorders (e.g., SLE). Use of immunomodulatory drugs (e.g., corticosteroids, cyclosporine) within 3 months. Severe infertility in the patient's partner (total motile sperm count <5 million).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nesting frequency. Timepoint: Before and after the intervention. Method of measurement: Patient file. | — |
Secondary
| Measure | Time frame |
|---|---|
| In vitro pregnancy. Timepoint: 14 days after embryo transfer. Method of measurement: ßhCG.;Clinical pregnancy. Timepoint: 3 weeks after transfer. Method of measurement: Vaginal ultrasound.;Number of ART sessions. Timepoint: After the intervention. Method of measurement: Patent file. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRobabe Hosseinisadat
Kerman University of Medical Sciences
Outcome results
None listed